间质干细胞介导的癌症基因治疗的进展。
Advances in mesenchymal stem cell-mediated gene therapy for cancer.
机构信息
Division of Surgery, School of Medicine, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland.
出版信息
Stem Cell Res Ther. 2010 Aug 9;1(3):25. doi: 10.1186/scrt25.
Abstract
Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are also considered immunoprivileged. This remarkable combination of properties has formed the basis for many studies investigating their potential as tumour-specific delivery vehicles for suicide genes, oncolytic viruses and secreted therapeutic proteins. The aim of the present review is to discuss the range of approaches that have been used to exploit the tumour-homing capacity of mesenchymal stem cells for gene delivery, and to highlight advances required to realize the full potential of this promising approach.
摘要
间充质干细胞对肿瘤及其转移灶具有天然的趋向性，并且被认为具有免疫特权。这种显著的特性组合为许多研究提供了基础，这些研究旨在探索间充质干细胞作为自杀基因、溶瘤病毒和分泌型治疗蛋白的肿瘤特异性递药载体的潜力。本综述的目的是讨论利用间充质干细胞的肿瘤归巢能力进行基因传递的各种方法，并强调实现这一有前途的方法的全部潜力所需的进展。
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Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment.间充质基质细胞单独或表达干扰素-β可抑制体内胰腺肿瘤，而抗炎治疗可拮抗这种作用。
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