Mohammadi M, Jaafari M R, Mirzaei H R, Mirzaei H
Hepatitis Research Center and Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Cancer Gene Ther. 2016 Sep;23(9):285-6. doi: 10.1038/cgt.2016.35. Epub 2016 Aug 19.
Cancer is one of the main problems in public health worldwide. Despite rapid advances in the diagnosis and treatment of cancer, the efficacy of current treatment strategies is still limited. There are promising new results in animal models whereby mesenchymal stem cells (MSCs) can be used as vehicles for targeted therapies. The use of MSCs as therapeutic biological vehicles in cell therapy has several advantages, including immune-silence, tumor tropism, easy and rapid isolation, ex vivo expansion, multilineage differentiation and the capacity to deliver a number of therapeutic agents. Some studies have shown that the microenvironment of the tumor provides a preferential niche for homing and survival of MSCs. Here, we have highlighted various applications of MSCs in cancer gene therapy.
癌症是全球公共卫生领域的主要问题之一。尽管癌症诊断和治疗取得了迅速进展，但当前治疗策略的疗效仍然有限。在动物模型中有一些很有前景的新成果，即间充质干细胞（MSCs）可作为靶向治疗的载体。在细胞治疗中使用MSCs作为治疗性生物载体有几个优点，包括免疫沉默、肿瘤嗜性、易于快速分离、体外扩增、多谱系分化以及递送多种治疗剂的能力。一些研究表明，肿瘤微环境为MSCs的归巢和存活提供了一个优先的生态位。在此，我们重点介绍了MSCs在癌症基因治疗中的各种应用。
