Johnson Philip J, Wiedmeyer Charles E, LaCarrubba Alison, Ganjam V K Seshu, Messer Nat T
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 East Campus Drive, Columbia, MO 65211, USA.
Vet Clin North Am Equine Pract. 2010 Aug;26(2):239-55. doi: 10.1016/j.cveq.2010.04.004. Epub 2010 Jun 9.
Although much has been written about laminitis in the context of its association with inflammatory processes, recognition is growing that most cases of laminitis examined by veterinarians in private practice are those associated with pasture grazing, obesity, and insulin resistance (IR). The term 'endocrinopathic laminitis' has been adopted to classify the instances of laminitis in which the origin seems to be more strongly associated with an underlying endocrinopathy, such as either IR or the influence of corticosteroids. Results of a recent study suggest that obesity and IR represent the most common metabolic and endocrinopathic predispositions for laminitis in horses. IR also plays an important role in the pathogenesis of laminitis that develops when some horses or ponies are allowed to graze pastures at certain times of the year. The term equine metabolic syndrome (EMS) has been proposed as a label for horses whose clinical examination results (including both physical examination and laboratory testing) suggest heightened risk for developing laminitis as a result of underlying IR.
尽管关于蹄叶炎与炎症过程相关性的著述颇多，但越来越多的人认识到，私人执业兽医检查的大多数蹄叶炎病例是与牧场放牧、肥胖和胰岛素抵抗（IR）相关的病例。“内分泌病性蹄叶炎”这一术语已被用于对蹄叶炎病例进行分类，在这些病例中，其病因似乎与潜在的内分泌病更密切相关，如IR或皮质类固醇的影响。最近一项研究的结果表明，肥胖和IR是马发生蹄叶炎最常见的代谢和内分泌病性易感因素。当一些马或矮种马在一年中的某些时候被允许在牧场放牧时，IR在由此引发的蹄叶炎发病机制中也起着重要作用。“马代谢综合征”（EMS）这一术语已被提议用于指代那些临床检查结果（包括体格检查和实验室检测）表明因潜在IR而发生蹄叶炎风险增加的马匹。
