Institute for Immunology and Infection Research, The University of Edinburgh, Edinburgh, UK.
Cell Cycle. 2010 Aug 1;9(15):2952-7. doi: 10.4161/cc.9.15.12358. Epub 2010 Aug 12.
Naive T lymphocytes maintain a quiescent resting state until they encounter antigen whereupon they undergo a switch in their metabolic program in preparation for proliferation and differentiation. This activation process involves a dramatic upregulation of protein synthesis that is essential for cell growth and the differentiation of effector function. An essential regulator of protein synthesis in T cells is the mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates both the availability of amino acids and the process of cap-dependent translation. Recent data indicate that mTOR influences activation and cell fate determination in T cells. We discuss these findings in light of what is currently known about the function of mTOR and its targets in CD8 T cells.
幼稚 T 淋巴细胞在遇到抗原之前保持静止的休息状态，然后在代谢程序中发生转变，为增殖和分化做准备。这个激活过程涉及到蛋白质合成的显著上调，这对于细胞生长和效应功能的分化是必不可少的。T 细胞中蛋白质合成的一个重要调节因子是哺乳动物雷帕霉素靶蛋白（mTOR），一种丝氨酸/苏氨酸激酶，它调节氨基酸的可用性和帽依赖性翻译的过程。最近的数据表明，mTOR 影响 T 细胞的激活和细胞命运决定。我们根据目前已知的 mTOR 及其在 CD8 T 细胞中的靶标功能来讨论这些发现。
