Pollizzi Kristen N, Powell Jonathan D
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Trends Immunol. 2015 Jan;36(1):13-20. doi: 10.1016/j.it.2014.11.005. Epub 2014 Dec 16.
Mammalian/mechanistic target of rapamycin (mTOR) is emerging as an important integrator of environmental cues critical for the regulation of T cell activation, differentiation, and function. Recent studies leveraging pharmacologic inhibition or T cell specific genetic deletion of signaling components in the mTOR pathway have provided important insights into the mechanisms involved, and have been informative in defining targets downstream of mTOR that promote immune regulation. However, these studies have also presented confusing and, at times, contradictory findings, highlighting the complexities involved in examining the mTOR pathway in distinct contexts. Here, we review current understanding of the roles of mTOR in T cell biology, highlighting emerging concepts and areas of investigation where the precise role of mTOR has yet to be fully discerned.
哺乳动物雷帕霉素靶蛋白（mTOR）正逐渐成为环境信号的重要整合者，这些信号对T细胞激活、分化及功能的调节至关重要。最近利用mTOR信号通路中信号成分的药物抑制或T细胞特异性基因缺失进行的研究，为其中涉及的机制提供了重要见解，并有助于确定mTOR下游促进免疫调节的靶点。然而，这些研究也呈现出令人困惑且有时相互矛盾的结果，凸显了在不同背景下研究mTOR信号通路所涉及的复杂性。在此，我们综述了目前对mTOR在T细胞生物学中作用的理解，强调了新兴概念以及mTOR的确切作用尚未完全明晰的研究领域。
