mTOR信号传导在调节性和效应性T细胞的分化及功能中所起的作用
mTOR signaling in the differentiation and function of regulatory and effector T cells.
作者信息
Zeng Hu, Chi Hongbo
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Curr Opin Immunol. 2017 Jun;46:103-111. doi: 10.1016/j.coi.2017.04.005. Epub 2017 May 20.
Abstract
The mechanistic target of rapamycin (mTOR) signaling pathway integrates environmental signals and cellular metabolism to regulate T cell development, activation and differentiation. Recent studies reveal the importance of exquisite control of mTOR activity for proper T cell function, and detailed molecular mechanisms that regulate mTOR signaling in different T cell subsets. Here, we review the latest advances in our understanding of the mTOR pathway and its regulation in the differentiation and function of regulatory T cells and effector T cells.
摘要
雷帕霉素的机制性靶标（mTOR）信号通路整合环境信号和细胞代谢，以调节T细胞的发育、激活和分化。最近的研究揭示了精确控制mTOR活性对于T细胞正常功能的重要性，以及调节不同T细胞亚群中mTOR信号的详细分子机制。在此，我们综述了在理解mTOR通路及其在调节性T细胞和效应T细胞的分化与功能中的调控方面的最新进展。
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