Formulation of creams with betamethasone dipropionate: evaluation of chemical stability.
作者信息
Băiţan Mariana, Gafiţanu Eliza, Lionte Mihaela, Moisuc Lăcrămioara
机构信息
Gr. T. Popa University of Medicine and Pharmacy, Iaşi School of Pharmacy, Department of Pharmaceutical Technology Antibiotice S. A. Iaşi.
出版信息
Rev Med Chir Soc Med Nat Iasi. 2010 Apr-Jun;114(2):600-4.
PMID:20701012
Abstract
The aim of this study was to investigate how the different excipients influenced the chemical stability of betamethasone dipropionate in creams. The chemical stability was evaluated by analyzing betamethasone related substance content. Transcutol is the excipient ensuring maximum stability to betamethasone. Incompatibilities between betamethasone dipropionate and hexylene glycol were observed. The pH values in the weak acid range confer chemical stability to betamethasone.
摘要
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