Ito Fabio A, Ito Kazuhiro, Coletta Ricardo D, Graner Edgard, de Almeida Oslei P, Lopes Márcio A
Department of Semiology and Oral Pathology, Piracicaba Dental School, State University of Campinas, Piracicaba, São Paulo, Brazil.
Anal Quant Cytol Histol. 2009 Oct;31(5):280-7.
To analyze the expression of ErbB-1 (Her-1 or EGFR), ErbB-2 (Her-2 or neu), ErbB-3 (Her-3) and ErbB-4 (Her-4) and their correlation in 3 different types of salivary gland tumors.
Immunohistochemical expression of epidermal growth factor (EGF), EGFR, ErbB-2, fatty acid synthase (FAS) and Ki-67 were analyzed in 41 pleomorphic adenoma (PA), in 30 mucoepidermoid carcinoma (MEC) and in 30 adenoid cystic carcinoma (ACC) and correlated with their histologic patterns.
EGF was more common in MEC and PA, but MEC had a higher percentage of strongly positive cases. EGFRc and EGFRm were both more frequent in MEC and ACC. Higher scores of ErbB-2c were observed in PA, followed by MEC and ACC. In contrast, higher scores of ErbB-2m were more common in MEC as compared to ACC and PA. FAS was most commonly found in PA and MEC. Moreover, MEC showed the highest percentage of strongly positive cases. Ki-67 was higher in MEC and ACC than in PA. From a correlation of immunomarkers with the histologic patterns, it was observed that cribriform ACC presented more expression of EGFR and high grade MEC showed a higher percentage of ErbB-2, FAS and Ki-67.
EGF, EGFR, ErbB-2 and FAS were commonly found and seem to be important in the tumorigenesis of salivary gland tumors, particularly in percentage of strongly positive cases. Ki-67 was higher in MEC and ACC than in PA. From a correlation of immunomarkers with the histologic patterns, it was observed that cribriform ACC presented more expression of EGFR and high grade MEC showed a higher percentage of ErbB-2, FAS and Ki-67.
EGF, EGFR, ErbB-2 and FAS were commonly found and seem to be important in the tumorigenesis of salivary gland tumors, particularly in MEC. (Anal Quant Cytol Histol 2009;31:280-287)
分析ErbB-1（Her-1或EGFR）、ErbB-2（Her-2或neu）、ErbB-3（Her-3）和ErbB-4（Her-4）在3种不同类型涎腺肿瘤中的表达及其相关性。
分析41例多形性腺瘤（PA）、30例黏液表皮样癌（MEC）和30例腺样囊性癌（ACC）中表皮生长因子（EGF）、EGFR、ErbB-2、脂肪酸合酶（FAS）和Ki-67的免疫组化表达，并将其与组织学模式相关联。
EGF在MEC和PA中更常见，但MEC中强阳性病例的百分比更高。EGFRc和EGFRm在MEC和ACC中均更常见。PA中观察到更高的ErbB-2c评分，其次是MEC和ACC。相比之下，与ACC和PA相比，MEC中更高的ErbB-2m评分更常见。FAS最常见于PA和MEC。此外，MEC中强阳性病例的百分比最高。MEC和ACC中的Ki-67高于PA。从免疫标志物与组织学模式的相关性来看，筛状ACC表现出更多的EGFR表达，高级别MEC中ErbB-2、FAS和Ki-67的百分比更高。
EGF、EGFR、ErbB-2和FAS普遍存在，似乎在涎腺肿瘤的发生中起重要作用，特别是在强阳性病例的百分比方面。MEC和ACC中的Ki-67高于PA。从免疫标志物与组织学模式的相关性来看，筛状ACC表现出更多的EGFR表达，高级别MEC中ErbB-2、FAS和Ki-67的百分比更高。
EGF、EGFR、ErbB-2和FAS普遍存在，似乎在涎腺肿瘤的发生中起重要作用，特别是在MEC中。（《分析定量细胞病理学与组织学》2009年；31:280 - 287）
