Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Psychophysiology. 2011 Apr;48(4):532-46. doi: 10.1111/j.1469-8986.2010.01085.x.
The "F" in FN400 denotes a more frontal scalp distribution relative to the morphologically similar N400 component-a distinction consistent with the hypothesized distinct roles of FN400 in familiarity memory versus N400 in language. However, no direct comparisons have substantiated these assumed dissimilarities. To this end, we manipulated short-term semantic priming during a recognition test. Semantic priming effects on N400 were indistinguishable from memory effects at the same latency, and semantic priming strongly modulated the "FN400," despite having no influence on familiarity memory. Thus, no evidence suggested either electrophysiological or functional differences between the N400 and FN400, and findings were contrary to the linking of the "FN400" to familiarity. Instead, it appears that semantic/conceptual priming (reflected in the N400) occurs during recognition tests and is frequently (mis)labeled as FN400 and attributed to familiarity.
FN400 中的“F”表示相对于形态相似的 N400 成分，头皮分布更靠前，这一区别与 FN400 在熟悉度记忆中的假设作用以及 N400 在语言中的作用相一致。然而，没有直接的比较可以证实这些假设的差异。为此，我们在识别测试中操纵了短期语义启动。在相同潜伏期内，N400 上的语义启动效应与记忆效应无法区分，尽管语义启动对“FN400”有强烈的调节作用，但对熟悉度记忆没有影响。因此，没有证据表明 N400 和 FN400 之间存在电生理或功能差异，研究结果与将“FN400”与熟悉度联系起来的观点相悖。相反，似乎是语义/概念启动（反映在 N400 中）发生在识别测试期间，并且经常（错误地）被标记为 FN400，并归因于熟悉度。
