School of Rehabilitation Therapy, Queen's University, Kingston, Ontario, Canada.
J Neuroeng Rehabil. 2010 Aug 11;7:39. doi: 10.1186/1743-0003-7-39.
Studying the changes that occur in motor unit potential trains (MUPTs) may provide insight into the extent of motor unit loss and neural re-organization resulting from nerve compression injury. The purpose of this study was to determine the feasibility of using decomposition-based quantitative electromyography (DQEMG) to study the pathophysiological changes associated with compression neuropathy.
The model used to examine compression neuropathy was carpal tunnel syndrome (CTS) due to its high prevalence and ease of diagnosis. Surface and concentric needle electromyography data were acquired simultaneously from the abductor pollicis brevis muscle in six individuals with severe CTS, eight individuals with mild CTS and nine healthy control subjects. DQEMG was used to detect intramuscular MUPTs during constant-intensity contractions and to estimate parameters associated with the surface- and needle-detected motor unit potentials (SMUPs and MUPs, respectively). MUP morphology and stability, SMUP morphology and motor unit number estimates (MUNEs) were compared among the groups using Kruskal-Wallis tests.
The severe CTS group had larger amplitude and longer duration MUPs and smaller MUNEs than the mild CTS and control groups, suggesting that the individuals with severe CTS had motor unit loss with subsequent collateral reinnervation, and that DQEMG using a constant-intensity protocol was sensitive to these changes. SMUP morphology and MUP complexity and stability did not significantly differ among the groups.
These results provide evidence that MUP amplitude parameters and MUNEs obtained using DQEMG, may be a valuable tool to investigate pathophysiological changes in muscles affected by compressive motor neuropathy to augment information obtained from nerve conduction studies. Although there were trends in many of these measures, in this study, MUP complexity and stability and SMUP parameters were, of limited value.
研究运动单位电位（MUP）的变化可能有助于深入了解神经压迫损伤导致的运动单位丧失和神经再组织的程度。本研究的目的是确定基于分解的定量肌电图（DQEMG）用于研究与压迫性神经病相关的病理生理变化的可行性。
用于检查压迫性神经病的模型是腕管综合征（CTS），因为它的发病率高且易于诊断。从 6 名严重 CTS 患者、8 名轻度 CTS 患者和 9 名健康对照者的拇指外展短肌中同时获取表面和同心针肌电图数据。使用 DQEMG 在恒强度收缩期间检测肌内 MUPT，并估计与表面和针检测到的运动单位电位（SMUP 和 MUP）相关的参数。使用 Kruskal-Wallis 检验比较各组之间的 MUP 形态和稳定性、SMUP 形态和运动单位数估计（MUNE）。
严重 CTS 组的 MUP 幅度和持续时间大于轻度 CTS 和对照组，MUNE 较小，提示严重 CTS 患者存在运动单位丧失，随后发生侧支再支配，使用恒强度方案的 DQEMG 对这些变化敏感。SMUP 形态和 MUP 复杂性和稳定性在组间无显著差异。
这些结果提供了证据，表明使用 DQEMG 获得的 MUP 幅度参数和 MUNE，可能是研究压迫性运动神经病影响肌肉的病理生理变化的有价值的工具，以补充神经传导研究获得的信息。尽管这些措施中的许多都有趋势，但在本研究中，MUP 复杂性和稳定性以及 SMUP 参数的价值有限。
