Infectious Diseases and Tropical Medicine Research Center, Jundishapoor University of Medical Sciences, Ahvaz, Iran.
J Infect Public Health. 2009;2(1):47-51. doi: 10.1016/j.jiph.2009.01.001. Epub 2009 Mar 6.
Prevalence of hepatitis C virus (HCV) in intravenous drug users (IDU) varies in different areas according to socioeconomic and geographical circumstances. The present study was performed to determine seroprevalence of HCV in IDU individuals in Ahvaz, Iran.
142 IDU patients were included in this retrospective study in Ahvaz southwest Iran from 2001 to 2006. Patients were placed in two groups determined by HCV Ab positive or negative status. Data were analyzed using SPSS for Windows (version 11.5; SPSS Inc., USA) software.
Out of total 142 cases, 74 persons (52.11%) had a positive HCV-Ab test according to the ELISA method. There was no difference in age, sex, level of education, residency and co-infection with HIV and hepatitis B virus between HCV-Ab positive (HAP) and HCV-Ab negative (HAN) groups (p>0.05). HCV-Ab positivity was significantly related to imprisonment and duration spent in prison [OR: 3.22, 95% (CI) 2.61-3.76, p<0.0001].
Patients with IDU constitute a high-risk group for acquisition of HCV infection. Transmission of HCV via sharing syringe and needle as well as blood transfusion has been a significant source of hepatitis C infection for patients with intravenous drug addiction.
根据社会经济和地理环境的不同，静脉吸毒者（IDU）中丙型肝炎病毒（HCV）的流行率在不同地区有所差异。本研究旨在确定伊朗阿瓦兹 IDU 个体中 HCV 的血清流行率。
本回顾性研究纳入了 2001 年至 2006 年期间来自伊朗西南部阿瓦兹的 142 名 IDU 患者。根据 HCV Ab 阳性或阴性状态将患者分为两组。使用 SPSS for Windows（版本 11.5；SPSS Inc.，美国）软件对数据进行分析。
在总共 142 例中，根据 ELISA 方法，74 例（52.11%） HCV-Ab 检测呈阳性。HCV-Ab 阳性（HAP）和 HCV-Ab 阴性（HAN）组在年龄、性别、教育程度、居住地以及 HIV 和乙型肝炎病毒共感染方面无差异（p>0.05）。HCV-Ab 阳性与监禁和入狱时间显著相关[比值比：3.22，95%置信区间（CI）：2.61-3.76，p<0.0001]。
IDU 患者是感染 HCV 的高危人群。共用注射器和针头以及输血传播 HCV 是静脉吸毒成瘾患者丙型肝炎感染的重要来源。
