Ghazaryan L, Smith L, Parker M, Flanigan C, Pulver W, Sullivan T, Carrascal A
Surveillance and Special Projects Unit, Bureau of STD Prevention and Epidemiology, AIDS Institute, New York State Department of Health, ESP, Corning Tower, Albany, NY, 12237, USA.
Division of Epidemiology, Evaluation and Research, New York State Department of Health, Corning Tower, ESP, Albany, NY, 12237, USA.
Matern Child Health J. 2016 Mar;20(3):550-5. doi: 10.1007/s10995-015-1853-4.
To identify factors associated with maternal hepatitis C virus (HCV) seroprevalence and transmission of HCV as identified by qualitative HCV ribonucleic acid (RNA) in the infants of human immunodeficiency virus (HIV) infected women delivering in New York State (NYS) in 2006.
In this retrospective cohort study of HIV-exposed infants born in NYS, leftover infant plasma from HIV diagnostic testing was de-identified and tested for HCV. If HCV antibodies were detected, a second specimen collected when the infant was >2 months old was tested for HCV qualitative RNA. Multivariate logistic regression was used to identify factors associated with HCV seropositivity.
In a final sample of 553 live birth events with perinatal HIV exposure, 21 (3.8 %) of tested infant specimens had HCV antibodies indicative of maternal HCV seropositivity. Maternal age at delivery of >35 years, Hispanic ethnicity, white race and injection drug use (IDU) were significantly associated with HCV seropositivity in multivariate analysis. No cases of HCV vertical transmission were identified among HCV exposed infant specimens.
This statewide population-based study of HIV-infected childbearing women shows HCV seroprevalence of 3.8 %. Maternal age of >35 years and IDU are the strongest predictors of HCV seropositivity. Although no viral transmission was documented, more comprehensive longitudinal testing would be required to conclude that HCV transmission did not occur.
确定与2006年在纽约州（NYS）分娩的人类免疫缺陷病毒（HIV）感染女性的婴儿中，母亲丙型肝炎病毒（HCV）血清阳性率及HCV传播相关的因素，其中HCV传播通过定性HCV核糖核酸（RNA）来确定。
在这项针对纽约州出生的HIV暴露婴儿的回顾性队列研究中，对HIV诊断检测后剩余的婴儿血浆进行去识别处理，并检测HCV。如果检测到HCV抗体，则对婴儿2个月大以后采集的第二份标本进行HCV定性RNA检测。采用多因素逻辑回归分析来确定与HCV血清阳性相关的因素。
在553例有围产期HIV暴露的活产事件的最终样本中，21例（3.8%）检测的婴儿标本有HCV抗体，表明母亲HCV血清阳性。在多因素分析中，分娩时母亲年龄大于35岁、西班牙裔、白人种族以及注射吸毒（IDU）与HCV血清阳性显著相关。在HCV暴露的婴儿标本中未发现HCV垂直传播的病例。
这项基于全州HIV感染育龄妇女的研究显示，HCV血清阳性率为3.8%。母亲年龄大于35岁和IDU是HCV血清阳性最强的预测因素。虽然未记录到病毒传播，但需要更全面的纵向检测才能得出HCV未发生传播的结论。
