Department of Epidemiology and Biostatistics, College of Public Health and Health Professions, University of Florida, FL, USA.
Sci Total Environ. 2010 Oct 1;408(21):4943-8. doi: 10.1016/j.scitotenv.2010.07.034. Epub 2010 Aug 10.
The association between background, enduring environmental exposure to polycyclic aromatic hydrocarbons (PAHs) and cardiovascular diseases has not been well studied in the general population. In this study, we used the National Health and Nutrition Examination Survey (NHANES) 2001-2004 to investigate the associations between eight monohydroxy PAHs (OH-PAHs) and self-report CVD. In a logistic regression model adjusting for cigarette smoking and other covariates, phenanthrene metabolite, 2-hydroxyphennathrene (2-PHEN), was significantly associated with self-report CVD. Compared to subjects within the lowest tertile of 2-PHEN, subjects within the middle and highest tertiles had higher self-report CVD (the 2nd tertile: AOR=1.29, 95%CI: 0.97-1.72; the 3rd tertile: AOR=1.45, 95%CI: 1.01-2.07; p for trend=0.04). In addition, fluorene metabolite (i.e. 2-hydroxyfluorene) also showed a marginally significant linear trend with self-report CVD (p for trend=0.07). Further studies are necessary to explore the associations between these highly prevalent pollutants and CVD.
在一般人群中，背景与多环芳烃（PAHs）的持久环境暴露之间的关联与心血管疾病的关联尚未得到很好的研究。在这项研究中，我们使用了 2001-2004 年的国家健康和营养调查（NHANES）来调查八种单羟基多环芳烃（OH-PAHs）与自我报告的 CVD 之间的关联。在调整吸烟和其他协变量的逻辑回归模型中，菲代谢物 2-羟基菲（2-PHEN）与自我报告的 CVD 显著相关。与 2-PHEN 最低三分位的受试者相比，中三分位和高三分位的受试者报告的 CVD 更高（第 2 三分位：OR=1.29，95%CI：0.97-1.72；第 3 三分位：OR=1.45，95%CI：1.01-2.07；趋势检验 p=0.04）。此外，芴代谢物（即 2-羟基芴）与自我报告的 CVD 也呈线性趋势，具有边缘显著性（趋势检验 p=0.07）。需要进一步的研究来探索这些高流行污染物与 CVD 之间的关联。
