Electronics Department, University of Alcalá, Alcalá de Henares, Madrid, Spain.
J Med Syst. 2012 Feb;36(1):103-11. doi: 10.1007/s10916-010-9450-y. Epub 2010 Mar 10.
Breast cancer, among women, is the second-most common cancer and the leading cause of cancer death. It has become a major health issue in the world over the past decades and its incidence has increased in recent years mostly due to increased awareness of the importance of screening and population ageing. Early detection is crucial in the effective treatment of breast cancer. Current mammogram screening may turn up many tiny abnormalities that are either not cancerous or are slow-growing cancers that would never progress to the point of killing a woman and might never even become known to her. Ideally a better screening method should find a way of distinguishing the dangerous, aggressive tumors that need to be excised from the more languorous ones that do not. This paper therefore proposes a new method of thermographic image analysis for automated detection of high tumor risk areas, based on independent component analysis (ICA) and on post-processing of the images resulting from this algorithm. Tests carried out on a database enable tumor areas of 4 × 4 pixels on an original thermographic image to be detected. The proposed method has shown that the appearance of a heat anomaly indicating a potentially cancerous zone is reflected as an independent source by ICA analysis of the YCrCb components; the set of available images in our small series is giving us a sensitivity of 100% and a specificity of 94.7%.
在女性中,乳腺癌是第二大常见癌症,也是癌症死亡的主要原因。在过去几十年中,它已成为全球的主要健康问题,近年来发病率上升,主要是由于对筛查的重要性的认识提高和人口老龄化。早期发现对于乳腺癌的有效治疗至关重要。目前的乳房 X 光筛查可能会发现许多微小的异常,这些异常要么不是癌症,要么是生长缓慢的癌症,永远不会发展到杀死女性的地步,甚至可能永远不会被她发现。理想情况下,一种更好的筛查方法应该找到一种方法来区分需要切除的危险、侵袭性肿瘤与不会发展的缓慢生长的肿瘤。因此,本文提出了一种基于独立成分分析(ICA)和对该算法得到的图像进行后处理的热成像分析新方法,用于自动检测高肿瘤风险区域。在一个数据库上进行的测试能够检测出原始热图像上 4×4 像素的肿瘤区域。该方法表明,潜在癌变区域的热异常表现通过 YCrCb 分量的 ICA 分析反映为一个独立的源;我们的小系列中可用的图像集为我们提供了 100%的灵敏度和 94.7%的特异性。
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