Departments of Rheumatology, School of Medicine, Kyung Hee University, Seoul, South Korea.
Int J Rheum Dis. 2010 Aug;13(3):e16-9. doi: 10.1111/j.1756-185X.2010.01528.x.
Tumor necrosis factor (TNF)-alpha is a pro-inflammatory cytokine that plays an important role in the pathogenesis of a variety of autoimmune diseases. TNF-alpha inhibitors have been shown to offer clinical benefits in the treatment of autoimmune and inflammatory disorders, including rheumatoid arthritis, ankylosing spondylitis (AS), and Crohn's disease. Occasionally, these agents have been associated with infectious complications because of their immunosuppressive activity. Globally, several cases of infections associated with TNF-alpha inhibitors have been reported. However, Aspergillus infection associated with etanercept is very rare. We report a case of chronic necrotizing pulmonary aspergillosis in a 51-year-old man with AS that developed after treatment with etanercept.
肿瘤坏死因子 (TNF)-α 是一种促炎细胞因子，在多种自身免疫性疾病的发病机制中发挥重要作用。TNF-α 抑制剂已被证明在治疗自身免疫和炎症性疾病方面具有临床益处，包括类风湿关节炎、强直性脊柱炎 (AS) 和克罗恩病。由于其免疫抑制活性，这些药物偶尔会与感染并发症相关联。在全球范围内，已经报告了几例与 TNF-α 抑制剂相关的感染病例。然而，与依那西普相关的曲霉菌感染非常罕见。我们报告了一例 51 岁男性 AS 患者在接受依那西普治疗后发生慢性坏死性肺曲霉病的病例。
