髓系来源的抑制细胞：移植耐受的天然调节者。
Myeloid-derived suppressor cells: natural regulators for transplant tolerance.
机构信息
Recanati/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY, USA.
出版信息
Hum Immunol. 2010 Nov;71(11):1061-6. doi: 10.1016/j.humimm.2010.08.001. Epub 2010 Aug 10.
Abstract
Myeloid derived suppressor cells (MDSC) contribute to the negative regulation of immune response in cancer patients. This review summarizes results on important issues related to MDSC biology, including expansion and activation of MDSC, phenotype, and subsets as well pathways and different mechanisms by which these cells exert their suppressive effect. Recent observations suggesting that MDSC may have roles in transplant tolerance are presented. Although therapeutic targeting and destruction of MDCS is of primary interest in cancer patients, in transplantation it will instead be necessary to induce, expand, and activate these cells; thus current possibilities for in vitro generation of MDSC are also discussed.
摘要
髓系来源的抑制细胞（MDSC）有助于癌症患者免疫反应的负调控。这篇综述总结了与 MDSC 生物学相关的重要问题的研究结果，包括 MDSC 的扩增和激活、表型和亚群，以及这些细胞发挥抑制作用的途径和不同机制。本文还介绍了最近的观察结果，表明 MDSC 可能在移植耐受中发挥作用。虽然在癌症患者中，靶向治疗和破坏 MDSC 是主要关注点，但在移植中，相反地需要诱导、扩增和激活这些细胞；因此，本文还讨论了目前体外生成 MDSC 的可能性。
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