Transplant Surgery Research Laboratory and Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Regenerative Medicine and Experimental Surgery, Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.
Front Immunol. 2022 Jul 6;13:917972. doi: 10.3389/fimmu.2022.917972. eCollection 2022.
Myeloid-derived suppressor cells (MDSC) are defined as a group of myeloid cells with potent immunoregulatory functions that have been shown to be involved in a variety of immune-related diseases including infections, autoimmune disorders, and cancer. In organ transplantation, MDSC promote tolerance by modifying adaptive immune responses. With aging, however, substantial changes occur that affect immune functions and impact alloimmunity. Since the vast majority of transplant patients are elderly, age-specific modifications of MDSC are of relevance. Furthermore, understanding age-associated changes in MDSC may lead to improved therapeutic strategies. Here, we provide a comprehensive update on the effects of aging on MDSC and discuss potential consequences on alloimmunity.
髓系来源的抑制细胞（MDSC）被定义为一群具有强大免疫调节功能的髓系细胞，已被证明参与多种与免疫相关的疾病，包括感染、自身免疫性疾病和癌症。在器官移植中，MDSC 通过调节适应性免疫反应来促进耐受。然而，随着年龄的增长，会发生大量影响免疫功能和同种异体免疫的变化。由于绝大多数移植患者都是老年人，因此 MDSC 的年龄特异性改变具有相关性。此外，了解 MDSC 与年龄相关的变化可能会导致治疗策略的改进。在这里，我们全面更新了衰老对 MDSC 的影响，并讨论了对同种异体免疫的潜在影响。
