Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Immunología de Trasplantes, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
Front Immunol. 2019 Mar 6;10:374. doi: 10.3389/fimmu.2019.00374. eCollection 2019.
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells of myeloid origin with a specific immune inhibitory function that negatively regulates the adaptive immune response. Since MDSC participate in the promotion of tolerance in the context of organ transplantation, therapeutic strategies that regulate the induction and development of MDSC have been the center of scientist attention. Here we review literature regarding induction of MDSC with demonstrated suppressive function among different types of allografts and their mechanism of action. While manipulation of MDSC represents a potential therapeutic approach for the promotion of donor specific tolerance in solid organ transplantation, further characterization of their specific phenotype, which distinguishes MDSC from non-suppressive myeloid cells, and detailed evaluation of the inhibitory mechanism that determines their suppressive function, is necessary for the realistic application of MDSC as biomarkers in health and disease and their potential use as immune cell therapy in organ transplantation.
髓系来源的抑制性细胞（MDSC）是一群异质性的、未成熟的髓系细胞，具有特定的免疫抑制功能，可负向调节适应性免疫反应。由于 MDSC 参与了器官移植中耐受的促进，因此调节 MDSC 的诱导和发展的治疗策略一直是科学家关注的焦点。本文综述了不同类型同种异体移植物中具有抑制功能的 MDSC 的诱导及其作用机制的相关文献。虽然 MDSC 的操纵代表了在实体器官移植中促进供体特异性耐受的一种潜在治疗方法，但为了将 MDSC 作为健康和疾病的生物标志物并将其作为免疫细胞治疗应用于器官移植，有必要进一步表征其特异性表型，将其与非抑制性髓系细胞区分开来，并详细评估决定其抑制功能的抑制机制。
