Kamb Mary L, Newman Lori M, Riley Patricia L, Mark Jennifer, Hawkes Sarah J, Malik Tasneem, Broutet Nathalie
Division of STD Prevention (DSTDP), International Activities Unit, U.S. Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd, NE, MS E-02, Atlanta, GA 30333, USA.
Obstet Gynecol Int. 2010;2010. doi: 10.1155/2010/312798. Epub 2010 Jul 14.
Congenital syphilis is the oldest recognized congenital infection, and continues to account for extensive global perinatal morbidity and mortality today. Serious adverse pregnancy outcomes caused by maternal syphilis infection are prevented with screening early in pregnancy and prompt treatment of women testing positive. Intramuscular penicillin, an inexpensive antibiotic on the essential medicine list of nations all over the world, effectively cures infection and prevents congenital syphilis. In fact, at a cost of $11-15 per disability adjusted life year (DALY) averted, maternal syphilis screening and treatment is among the most cost-effective public health interventions in existence. Yet implementation of this basic public health intervention is sporadic in countries with highest congenital syphilis burden. We discuss the global burden of this devastating disease, current progress and ongoing challenges for its elimination in countries with highest prevalence, and next steps in ensuring a world free of preventable perinatal deaths caused by syphilis.
先天性梅毒是最早被认识的先天性感染疾病，如今在全球范围内仍导致大量围产期发病和死亡。通过孕期早期筛查和对检测呈阳性的女性进行及时治疗，可以预防由母体梅毒感染引起的严重不良妊娠结局。肌内注射青霉素是一种列入世界各国基本药物清单的廉价抗生素，能有效治愈感染并预防先天性梅毒。事实上，每避免一个伤残调整生命年（DALY）的成本为11 - 15美元，孕产妇梅毒筛查和治疗是现有最具成本效益的公共卫生干预措施之一。然而，在先天性梅毒负担最高的国家，这一基本公共卫生干预措施的实施情况并不稳定。我们讨论了这种毁灭性疾病的全球负担、在患病率最高的国家消除该疾病的当前进展和持续挑战，以及确保实现一个无梅毒所致可预防围产期死亡的世界的下一步措施。
