Pandurangan Annamalai, Khosa Ratan Lal, Hemalatha Siva
School of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India.
J Asian Nat Prod Res. 2010 Aug;12(8):691-5. doi: 10.1080/10286020.2010.497997.
Solasodine (1) was isolated for the first time from the roots of Solanum trilobatum Linn., a member of the Solanaceae, and assessed for its presumed antinociceptive activity using several experimental murine models, viz. the writhing, formalin, and hot plate tests. When used at doses of 2, 4, and 8 mg/kg, this steroidal alkaloid caused a significant and dose-dependent decrease in the nociception induced by an intraperitoneal injection of acetic acid (p < 0.001). It also led to a significant reduction of the painful sensation caused by formalin in both phases of the formalin test (p < 0.001). Furthermore, the alkaloid produced a significant increase in the reaction time in the hot plate test (p < 0.001). These results suggest that solasodine elicited antinociceptive activity through both central and peripheral mechanisms.
澳洲茄碱（1）首次从茄科植物三叉苦（Solanum trilobatum Linn.）的根中分离出来，并使用几种实验性小鼠模型，即扭体试验、福尔马林试验和热板试验，对其假定的抗伤害感受活性进行了评估。当以2、4和8 mg/kg的剂量使用时，这种甾体生物碱可使腹腔注射醋酸诱导的伤害感受显著且呈剂量依赖性降低（p < 0.001）。它还导致福尔马林试验两个阶段中福尔马林引起的疼痛感觉显著减轻（p < 0.001）。此外，该生物碱使热板试验中的反应时间显著增加（p < 0.001）。这些结果表明，澳洲茄碱通过中枢和外周机制发挥抗伤害感受活性。
