款冬花中的黄酮类化合物和酚酸衍生物

[Flavonoids and phenolic acid derivatives from flos farfarae].

作者信息

Wu Di, Zhang Mian, Zhang Chaofeng, Wang Zhengtao

机构信息

Research Department of Pharmacognosy, China Pharmaceutical University, Nanjing 211198, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2010 May;35(9):1142-4. doi: 10.4268/cjcmm20100912.

DOI:10.4268/cjcmm20100912

PMID:20707069

Abstract

OBJECTIVE

To investigate the chemical constituents of the flower buds of Tussilago farfara.

METHOD

The chemical constituents were isolated by silica gel and Sephadex LH-20 column chromatography, and structurally elucidated by spectral evidence together with physiochemical properties.

RESULT

Seven flavonoids, quercetin (1), quercetin-3-O-beta-D-glucopyranoside (2), quercetin-4'-O-beta-D-glucopyranoside (3), hyperoside (4), rutin (5), kaempferol (6), kaempferol-3-O-alpha-L-rhamnopyranosyl-(1-6)-beta-D-glucopyranoside (7), together with eight phenolic acid derivatives, caffeic acid (8), methyl caffeate (9), ethyl caffeate (10), (E)-2,5-dihydroxycinnamic acid (11), 3,4-di-O-caffeoylquinic acid (12), 4,5-di-O-caffeoylquinic acid (13), methyl4,5-di-O-caffeoylquinate (14) and chlorogenic acid (15) were isolated from the flower buds of Tussilago farfara.

CONCLUSION

Compounds 7, 9-14 are isolated from this plant, also from this genus, for the first time.

摘要

目的

研究款冬花蕾的化学成分。

方法

采用硅胶柱色谱和葡聚糖凝胶LH - 20柱色谱分离化学成分，并结合光谱数据和理化性质进行结构鉴定。

结果

从款冬花蕾中分离得到7种黄酮类化合物，分别为槲皮素（1）、槲皮素 - 3 - O - β - D - 吡喃葡萄糖苷（2）、槲皮素 - 4'- O - β - D - 吡喃葡萄糖苷（3）、金丝桃苷（4）、芦丁（5）、山柰酚（6）、山柰酚 - 3 - O - α - L - 鼠李吡喃糖基 -（1→6）- β - D - 吡喃葡萄糖苷（7），以及8种酚酸衍生物，分别为咖啡酸（8）、咖啡酸甲酯（9）、咖啡酸乙酯（10）、（E）- 2,5 - 二羟基肉桂酸（11）、3,4 - 二 - O - 咖啡酰奎宁酸（12）、4,5 - 二 - O - 咖啡酰奎宁酸（13）、甲基4,5 - 二 - O - 咖啡酰奎宁酸（14）和绿原酸（15）。