快速追踪组织者基因表达。
On the fast track to organizer gene expression.
机构信息
Department of Biochemistry, University of Washington, Seattle, 98195-7350, USA.
出版信息
Dev Cell. 2010 Aug 17;19(2):190-2. doi: 10.1016/j.devcel.2010.07.020.
Abstract
Many embryonic species are initially transcriptionally quiescent after fertilization. In this issue of Developmental Cell, Blythe et al. reveal that beta-catenin acts very early in Xenopus development to specifically modify the chromatin of organizer genes, poising them for rapid activation when transcription begins.
摘要
许多胚胎物种在受精后最初是转录沉默的。在本期《发育细胞》中，Blythe 等人揭示了β-连环蛋白在 Xenopus 发育的早期就非常活跃，专门修饰组织者基因的染色质，使其在转录开始时能够快速激活。
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Beta-catenin hits chromatin: regulation of Wnt target gene activation.β-连环蛋白作用于染色质：Wnt靶基因激活的调控
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pygopus Encodes a nuclear protein essential for wingless/Wnt signaling.pygopus编码一种无翅型/ Wnt信号传导所必需的核蛋白。
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