暴发型 1 型糖尿病患者的血清 1,5-脱水葡萄糖醇水平低于 2 型糖尿病患者。
Serum 1,5-anhydroglucitol levels in patients with fulminant type 1 diabetes are lower than those in patients with type 2 diabetes.
机构信息
Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan.
出版信息
Clin Biochem. 2010 Oct;43(15):1265-7. doi: 10.1016/j.clinbiochem.2010.08.001. Epub 2010 Aug 12.
OBJECTIVES
We investigated clinical relevance of serum 1,5-anhydroglucitol (1,5-AG) levels in fulminant type 1 diabetes mellitus (FT1DM) patients, because 1,5-AG is known to reflect short term glycemic control.
DESIGN AND METHODS
Subjects comprised 7 patients with FT1DM and 32 patients with type 2 diabetes mellitus (T2DM) with HbA1c <8.5%. All of them have never been treated for diabetes.
RESULTS
HbA(1C) showed no significant difference between both groups. On the other hand, serum 1,5-AG levels were significantly lower in the FT1DM patients than in the T2DM patients. Serum 1,5-AG levels were < 5.0 μg/ml in 6 of 7 (86%) FT1DM patients, compared with only 1 of 32 (3%) T2DM patients.
CONCLUSIONS
Serum 1,5-AG levels were lower in the FT1DM patients than in the T2DM patients. Serum 1,5-AG, but not HbA(1C), reflects short-term exacerbation of glycemia in patients with FT1DM.
目的
我们研究了血清 1,5-脱水葡萄糖醇（1,5-AG）水平在暴发性 1 型糖尿病（FT1DM）患者中的临床相关性，因为 1,5-AG 已知反映短期血糖控制。
设计和方法
受试者包括 7 例 FT1DM 患者和 32 例糖化血红蛋白（HbA1c）<8.5%的 2 型糖尿病（T2DM）患者。他们都从未接受过糖尿病治疗。
结果
两组之间 HbA1C 无显著差异。另一方面，FT1DM 患者的血清 1,5-AG 水平明显低于 T2DM 患者。7 例 FT1DM 患者中有 6 例（86%）的血清 1,5-AG 水平<5.0μg/ml，而 32 例 T2DM 患者中只有 1 例（3%）。
结论
FT1DM 患者的血清 1,5-AG 水平低于 T2DM 患者。血清 1,5-AG，而不是 HbA1C，反映了 FT1DM 患者短期血糖恶化。
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