由不依赖Cx36的视杆通路诱发的外侧膝状体中的视觉反应。
Visual responses in the lateral geniculate evoked by Cx36-independent rod pathways.
作者信息
Brown Timothy M, Allen Annette E, Wynne Jonathan, Paul David L, Piggins Hugh D, Lucas Robert J
机构信息
Faculty of Life Sciences, University of Manchester, Manchester, UK.
出版信息
Vision Res. 2011 Jan 28;51(2):280-7. doi: 10.1016/j.visres.2010.08.010. Epub 2010 Aug 13.
Abstract
Emerging evidence indicates rods can communicate with retinal ganglion cells (RGCs) via pathways that do not involve gap-junctions. Here we investigated the significance of such pathways for central visual responses, using mice lacking a key gap junction protein (Cx36(-/-)) and carrying a mutation that disrupts cone phototransduction (Gnat2(cpfl3)). Electrophysiological recordings spanning the lateral geniculate revealed rod-mediated ON and OFF visual responses in virtually every cell from all major anatomical sub-compartments of this nucleus. Hence, we demonstrate that one or more classes of RGC receive input from Cx36-independent rod pathways and drive extensive ON and OFF responses across the visual thalamus.
摘要
新出现的证据表明，视杆细胞可以通过不涉及缝隙连接的途径与视网膜神经节细胞（RGCs）进行通讯。在这里，我们使用缺乏关键缝隙连接蛋白（Cx36(-/-)）且携带破坏视锥细胞光转导的突变（Gnat2(cpfl3)）的小鼠，研究了此类途径对中枢视觉反应的重要性。跨越外侧膝状体的电生理记录显示，在该核所有主要解剖亚区的几乎每个细胞中都存在视杆细胞介导的开和关视觉反应。因此，我们证明，一类或多类视网膜神经节细胞接收来自不依赖Cx36的视杆细胞途径的输入，并驱动整个视觉丘脑广泛的开和关反应。
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