Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330 Ankara, Turkey.
J Ethnopharmacol. 2010 Nov 11;132(2):408-13. doi: 10.1016/j.jep.2010.08.004. Epub 2010 Aug 13.
The leaves, flowers, and whole aerial parts of Verbascum L. (Scrophulariaceae) species are used to treat eczema and other types of inflammatory skin conditions and as a desiccant for wounds in Turkish traditional medicine. In the present study, the methanolic extracts of 13 Verbascum species growing in Turkey, including Verbascum chionophyllum Hub.-Mor., Verbascum cilicicum Boiss., Verbascum dudleyanum (Hub.-Mor.) Hub.-Mor., Verbascum lasianthum Boiss., Verbascum latisepalum Hub.-Mor., Verbascum mucronatum Lam., Verbascum olympicum Boiss., Verbascum pterocalycinum var. mutense Hub.-Mor., Verbascum pycnostachyum Boiss. & Heldr., Verbascum salviifolium Boiss., Verbascum splendidum Boiss., Verbascum stachydifolium Boiss. & Heldr and Verbascum uschackense (Murb.) Hub.-Mor. were assessed for their in vivo wound healing activity.
In vivo wound healing activity of the plants were evaluated by linear incision and circular excision experimental models subsequently histopathological analysis. The healing potential was comparatively assessed with a reference ointment Madecassol(®), which contains 1% extract of Centella asiatica.
The methanolic extracts of Verbascum olympicum, Verbascum stachydifolium and Verbascum uschackense demonstrated the highest activities on the both wound models. Moreover, the methanolic extracts of Verbascum latisepalum, Verbascum mucronatum, and Verbascum pterocalycinum var. mutense were found generally highly effective. On the other hand, the rest of the species did not show any remarkable wound healing effect. Results of the present study support the continued and expanded utilization of these plant species employed in Turkish folk medicine.
The experimental study revealed that Verbascum species display remarkable wound healing activity.
在土耳其传统医学中，列当科（Scrophulariaceae）物种的叶、花和整个地上部分被用于治疗湿疹和其他类型的炎症性皮肤疾病，并用作伤口干燥剂。在本研究中，对包括 Verbascum chionophyllum Hub.-Mor.、Verbascum cilicicum Boiss.、Verbascum dudleyanum（Hub.-Mor.）Hub.-Mor.、Verbascum lasianthum Boiss.、Verbascum latisepalum Hub.-Mor.、Verbascum mucronatum Lam.、Verbascum olympicum Boiss.、Verbascum pterocalycinum var. mutense Hub.-Mor.、Verbascum pycnostachyum Boiss. & Heldr.、Verbascum salviifolium Boiss.、Verbascum splendidum Boiss.、Verbascum stachydifolium Boiss. & Heldr. 和 Verbascum uschackense（Murb.）Hub.-Mor. 在内的 13 种土耳其境内生长的列当属植物的甲醇提取物进行了评估，以确定其体内伤口愈合活性。
通过线性切口和圆形切除实验模型评估植物的体内伤口愈合活性，随后进行组织病理学分析。将愈合潜力与含有 1%积雪草提取物的对照软膏 Madecassol(®)进行比较评估。
Verbascum olympicum、Verbascum stachydifolium 和 Verbascum uschackense 的甲醇提取物在两种伤口模型中均表现出最高的活性。此外，Verbascum latisepalum、Verbascum mucronatum 和 Verbascum pterocalycinum var. mutense 的甲醇提取物通常具有高度的有效性。另一方面，其余的物种没有显示出任何明显的伤口愈合效果。本研究的结果支持继续扩大使用这些在土耳其民间医学中使用的植物物种。
实验研究表明，列当科物种具有显著的伤口愈合活性。
