体内病毒感染时 STAT 的激活：干扰素在哪里？
STAT activation during viral infection in vivo: where's the interferon?
机构信息
Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
出版信息
Cell Host Microbe. 2010 Aug 19;8(2):132-5. doi: 10.1016/j.chom.2010.07.011.
Abstract
In this issue of Cell Host & Microbe, O'Gorman et al. (2010) identify a key role for early TLR2-mediated IL-6 production and STAT3 activation in generating protective immunity against poxviruses. These findings highlight the importance of early inflammatory cytokine production in antiviral defense and have implications for enhancing vaccination efficacy.
摘要
在本期《细胞宿主与微生物》中，O'Gorman 等人（2010 年）确定了早期 TLR2 介导的 IL-6 产生和 STAT3 激活在产生针对痘病毒的保护性免疫中的关键作用。这些发现强调了早期炎症细胞因子产生在抗病毒防御中的重要性，并对增强疫苗效力具有重要意义。
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