当代人类遗传学在衰老研究中的策略。
Contemporary human genetic strategies in aging research.
机构信息
Scripps Translational Science Institute & Scripps Health, La Jolla, CA 92037, USA.
出版信息
Ageing Res Rev. 2011 Apr;10(2):191-200. doi: 10.1016/j.arr.2010.07.005. Epub 2010 Aug 10.
Abstract
Human aging is a complex, multifactorial process influenced by a number of genetic and non-genetic factors. This article first reviews genetic strategies for human aging research and considers the advantages and disadvantages of each. We then discuss the issue of phenotypic definition for genetic studies of aging, including longevity/life span, as well as disease-free survival and other endophenotypes. Finally, we argue that extensions of this area of research, including incorporation of gene×environment interactions, multivariate phenotypes, integration of functional genomic annotations, and exploitation of orthology - many of which are already initiated and ongoing - are critical to advancing this field.
摘要
人类衰老过程是一个复杂的、多因素的过程，受到许多遗传和非遗传因素的影响。本文首先回顾了人类衰老研究的遗传策略，并考虑了每种策略的优缺点。然后，我们讨论了遗传研究中衰老的表型定义问题，包括长寿/寿命、无疾病生存和其他表型。最后，我们认为，这一研究领域的扩展，包括基因-环境相互作用的纳入、多变量表型、功能基因组注释的整合以及同源性的利用——其中许多已经开始并正在进行——对于推进这一领域至关重要。
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