Babatunde S K, Salami A K, Fabiyi J P, Agbede O O, Desalu O O
Department of Medicale Microbiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Ann Afr Med. 2010 Jul-Sep;9(3):123-8. doi: 10.4103/1596-3519.68356.
To determine the prevalence, severity and pattern of intestinal parasitic infestation in HIV-seropositive patients.
A Cross-sectional study from January 2007 to December 2008.Patients were recruited from the HIV clinics of the hospital. Paired blood and single stool specimens were collected from each patient. The stool sample was investigated for intestinal parasites while the blood sample was tested for antibodies to HIV-1 and 2. HIV-seropositive subjects also had CD4 + cells count done.
Ninety each of stool and blood samples were collected from HIV-seropositive and HIV-seronegative patients. Four species each of helminthes and protozoan parasites and three species of coccidian parasites were isolated from the stool of both HIV-seropositive and seronegative subjects. The prevalence of these parasites was two and a halve times higher among the HIV seropositive patients than the seronegative ones. The range of CD4 cells count was 20-680 cells/microl with a median of 259 cells/microl. Patients with CD4+ count <200/microl had more coccidian parasites in their stool and also had higher prevalence of intestinal polyparasitism ranging from 2 to 4 different species per stool sample.
The frequency of both AIDS defining and non- AIDS defining intestinal parasitic infestation was higher among the HIV infected patients. Patients' CD4+ cells count was an important determinant of the rate and number of parasitic infestation.
确定HIV血清阳性患者肠道寄生虫感染的患病率、严重程度及模式。
2007年1月至2008年12月进行的一项横断面研究。从医院的HIV诊所招募患者。采集每位患者的配对血液和单一粪便标本。对粪便样本进行肠道寄生虫检测，对血液样本进行HIV-1和HIV-2抗体检测。HIV血清阳性受试者还进行了CD4 +细胞计数。
从HIV血清阳性和血清阴性患者中各采集了90份粪便和血液样本。在HIV血清阳性和血清阴性受试者的粪便中均分离出四种蠕虫和原生动物寄生虫以及三种球虫寄生虫。这些寄生虫在HIV血清阳性患者中的患病率比血清阴性患者高2.5倍。CD4细胞计数范围为20 - 680个/微升，中位数为259个/微升。CD4 +计数<200/微升的患者粪便中的球虫寄生虫更多，肠道多重寄生虫感染的患病率也更高，每个粪便样本中有2至4种不同的寄生虫。
HIV感染患者中艾滋病界定和非艾滋病界定的肠道寄生虫感染频率均较高。患者的CD4 +细胞计数是寄生虫感染率和感染数量的重要决定因素。
