Han Ye Won, Kim Hyung Ok, Park Sung Hwan, Park Young Min
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ann Dermatol. 2010 Aug;22(3):307-11. doi: 10.5021/ad.2010.22.3.307. Epub 2010 Aug 5.
Discoid lupus erythematosus (DLE), which is a cutaneous form of lupus erythematosus (LE), is generally refractory to a wide range of topical or systemic therapies. Although the main treatment option for DLE is topical steroids, it is often ineffective or likely to produce long-term side effects. New drugs, including tacrolimus and pimecrolimus, have been developed to overcome the adverse effects of steroids and treat the lesions of DLE for a prolonged period. We herein report 4 cases of facial DLE successfully treated with therapeutic adjuvants, topical tacrolimus or pimecrolimus.
盘状红斑狼疮(DLE)是红斑狼疮(LE)的一种皮肤形式,通常对多种局部或全身治疗均具有难治性。尽管DLE的主要治疗选择是局部使用类固醇,但它往往无效或可能产生长期副作用。包括他克莫司和吡美莫司在内的新药已被开发出来,以克服类固醇的不良反应并长期治疗DLE的皮损。我们在此报告4例面部DLE患者通过治疗辅助剂、局部使用他克莫司或吡美莫司成功治愈的病例。