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系统性羟氯喹与外用吡美莫司联合治疗盘状狼疮性脱发的疗效观察

Resolution of Discoid Lupus Alopecia With Systemic Hydroxychloroquine and Topical Pimecrolimus Combination Therapy.

作者信息

Liang Kristine R, Lee Cynthia, Hilts Alexis, Greenberg H L

机构信息

School of Medicine, Kirk Kerkorian School of Medicine at University of Nevada Las Vegas, Las Vegas, USA.

Transitional Year Residency Program, Sunrise Health Graduate Medical Education (GME) Consortium, HCA Healthcare, Las Vegas, USA.

出版信息

Cureus. 2024 Jun 28;16(6):e63419. doi: 10.7759/cureus.63419. eCollection 2024 Jun.

DOI:10.7759/cureus.63419
PMID:39077308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11284255/
Abstract

Discoid lupus erythematosus (DLE) is an autoimmune skin condition that is typically part of the cutaneous manifestation of systemic lupus erythematosus (SLE). DLE is characterized by erythematous patches that can progress to depigmentation and alopecia, leading to scarring and permanent hair loss if left untreated. Herein, we present a unique case of localized DLE on the scalp in a 46-year-old female with no prior history of autoimmune disorders. The patient underwent several medication trials, including intralesional corticosteroids, topical calcineurin inhibitors, topical corticosteroids, and systemic hydroxychloroquine, with limited success in treating her discoid alopecia. Subsequently, a combination therapy of oral hydroxychloroquine and topical pimecrolimus significantly improved her scalp lesion. This case highlights the efficacy of combination therapy in managing localized DLE, providing valuable insights for future research focused on DLE alopecia management and optimizing treatment strategies for similar cases.

摘要

盘状红斑狼疮（DLE）是一种自身免疫性皮肤病，通常是系统性红斑狼疮（SLE）皮肤表现的一部分。DLE的特征是红斑斑块，可发展为色素脱失和脱发，如果不治疗，会导致瘢痕形成和永久性脱发。在此，我们报告一例46岁无自身免疫性疾病病史的女性头皮局限性DLE的独特病例。该患者接受了多种药物试验，包括皮损内注射皮质类固醇、外用钙调神经磷酸酶抑制剂、外用皮质类固醇和系统性羟氯喹，但在治疗盘状脱发方面效果有限。随后，口服羟氯喹和外用吡美莫司的联合治疗显著改善了她的头皮病变。该病例突出了联合治疗在管理局限性DLE方面的疗效，为未来专注于DLE脱发管理及优化类似病例治疗策略的研究提供了有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/df358e947f8e/cureus-0016-00000063419-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/c42d5fa5f368/cureus-0016-00000063419-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/c1da2f5b7218/cureus-0016-00000063419-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/d706c700108b/cureus-0016-00000063419-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/689857c2c0ab/cureus-0016-00000063419-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/df358e947f8e/cureus-0016-00000063419-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/c42d5fa5f368/cureus-0016-00000063419-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/c1da2f5b7218/cureus-0016-00000063419-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/d706c700108b/cureus-0016-00000063419-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/689857c2c0ab/cureus-0016-00000063419-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/165f/11284255/df358e947f8e/cureus-0016-00000063419-i05.jpg

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本文引用的文献

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Interventions for cutaneous disease in systemic lupus erythematosus.治疗系统性红斑狼疮皮肤病变的干预措施。
Cochrane Database Syst Rev. 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2.
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