Department of Kinesiology, University of Waterloo, 200 University Ave W, Waterloo, ON, N2L 3G1, Canada.
Exp Brain Res. 2010 Sep;205(4):465-77. doi: 10.1007/s00221-010-2381-5. Epub 2010 Aug 14.
Bimanual movement training (BMT) may be an effective rehabilitative protocol for movement-related deficits following a stroke; however, it is unclear how varying types of BMT induce cortical adaptations in the healthy population. Moreover, we lack a methodology to measure cortical adaptations in response to modes of movement training. Therefore, the present study measured the cued movement-related potential (MRP) to investigate cortical adaptations during cued inphase versus antiphase BMT that transferred to a unimanual task and how cortical modulations related to behavior. Three specific hypotheses were investigated: (1) cued inphase BMT would induce cortical adaptations within regions subserving motor preparation and movement execution, (2) repetitive cued unimanual training would induce cortical activity modulations associated with motor execution, and (3) increased cortical activity would be associated with enhanced performance. On three separate days, EEG was recorded from 22 electrodes during three types of cued movement training: inphase BMT, antiphase BMT and repetitive unimanual movement, in addition to pre- and post-training unimanual movement trials involving cued right wrist flexion. The MRP was measured for each repetition during each trial. Results showed a significant training-related increase in preparatory activation correlated with a behavioral enhancement following cued inphase BMT. This effect was not attributable to a change in arousal. No significant training-related modulation occurred in response to cued antiphase BMT or repetitive unimanual movement training. These results suggest that cortical adaptations in relation to the preparation of a cued movement enhance in response to cued inphase BMT, and the MRP is an effective measurement tool to assess training-related adaptations in response to inphase BMT specifically.
双手运动训练（BMT）可能是一种有效的针对中风后运动相关缺陷的康复方案；然而，目前尚不清楚不同类型的 BMT 如何在健康人群中引起皮质适应性变化。此外，我们缺乏一种方法来测量皮质适应性变化以响应运动训练模式。因此，本研究测量了提示运动相关电位（MRP），以研究在提示同相和反相 BMT 期间的皮质适应性变化，这些变化可以转移到单手任务中，以及皮质调节与行为的关系。研究调查了三个具体假设：（1）提示同相 BMT 将引起运动准备和运动执行区域的皮质适应性变化，（2）重复提示单手训练将引起与运动执行相关的皮质活动调节，以及（3）增加的皮质活动将与增强的表现相关。在三个不同的日子里，在三种提示运动训练期间，从 22 个电极记录了 22 个电极的 EEG：同相 BMT、反相 BMT 和重复单手运动，以及在提示右腕屈曲的单手运动训练之前和之后的训练试验。在每个试验的每次重复期间测量了 MRP。结果表明，与提示同相 BMT 相关的准备激活的训练相关性增加，与提示同相 BMT 后的行为增强相关。这种效果不是由于觉醒的变化引起的。在响应提示反相 BMT 或重复单手运动训练时，没有发生明显的与训练相关的调节。这些结果表明，与提示运动的准备相关的皮质适应性变化会增强对提示同相 BMT 的反应，并且 MRP 是一种有效的测量工具，可以专门评估与提示同相 BMT 相关的训练适应性变化。
