Department of Psychiatry, University of Cambridge, UK.
Eur Arch Psychiatry Clin Neurosci. 2011 Feb;261(1):59-67. doi: 10.1007/s00406-010-0133-y. Epub 2010 Aug 15.
The negative symptoms of schizophrenia have been considered to be a psychiatric form of the frontal lobe syndrome. However, no studies have compared these two disorders at the clinical level. In this study, 12 negative symptom schizophrenic patients and 11 patients with behavioural variant frontotemporal dementia (bv-FTD) were rated for negative symptoms and for occurrence of frontal lobe behaviours in everyday life. They were also rated for speech disorder and were given a series of executive tests. Both patient groups showed positive ratings on negative symptoms and frontal lobe behaviours in daily life; however, the schizophrenic patients had higher negative symptom scores and the bv-FTD patients had higher carer ratings on frontal behaviours in daily life. Both groups were impaired on the executive tests, but the bv-FTD patients showed significantly greater impairment on verbal fluency and a test requiring inhibition of prepotent responses. A minority of the bv-FTD patients unexpectedly showed speech abnormalities typically associated with schizophrenia. The findings indicate that the negative syndrome in schizophrenia and the frontal lobe syndrome resemble each other clinically in important respects. Some of the differences may be attributable to the additional presence of disinhibition in the frontal lobe syndrome.
精神分裂症的阴性症状被认为是额叶综合征的一种精神科形式。然而，尚无研究在临床层面比较这两种疾病。在这项研究中，对 12 名阴性症状精神分裂症患者和 11 名行为变异额颞叶痴呆（bv-FTD）患者进行了阴性症状评估以及日常生活中额叶行为的发生评估。他们还接受了言语障碍评估，并进行了一系列执行功能测试。两组患者的阴性症状和日常生活中的额叶行为均呈阳性评分；然而，精神分裂症患者的阴性症状评分更高，而 bv-FTD 患者的日常生活中额叶行为的照料者评分更高。两组患者的执行功能测试均受损，但 bv-FTD 患者在词语流畅性和需要抑制优势反应的测试中表现出明显更大的损伤。少数 bv-FTD 患者出人意料地出现了与精神分裂症相关的言语异常。研究结果表明，精神分裂症的阴性综合征和额叶综合征在重要方面具有相似的临床特征。一些差异可能归因于额叶综合征中存在的去抑制。
