Mendez Mario F
Department of Neurology.
Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Neuropsychiatr Dis Treat. 2018 Feb 26;14:657-662. doi: 10.2147/NDT.S156084. eCollection 2018.
Studies suggest a relationship of manic behavior and bipolar disorder (BD) with behavioral variant frontotemporal dementia (bvFTD). The nature of this relationship is unclear. This report presents a patient with initial manic behavior as the main manifestation of familial bvFTD from a novel progranulin (GRN) mutation. In contrast, there are other reports of a long background of BD preceding a diagnosis of bvFTD. A review of the literature and this patient suggest that manic symptoms result from damage to right frontotemporal neural structures from longstanding BD, as well as from bvFTD and other focal neurological disorders. In addition, there is a subgroup of patients with a probable genetic predisposition to both BD and bvFTD.
研究表明，躁狂行为和双相情感障碍（BD）与行为变异型额颞叶痴呆（bvFTD）之间存在关联。这种关联的性质尚不清楚。本报告介绍了一名以初始躁狂行为为主要表现的家族性bvFTD患者，其携带一种新的原颗粒蛋白（GRN）突变。相比之下，也有其他报告称，在bvFTD诊断之前有长期的BD病史。对文献的回顾以及该患者的情况表明，躁狂症状是由长期BD导致的右侧额颞叶神经结构损伤引起的，bvFTD和其他局灶性神经系统疾病也会导致这种损伤。此外，有一个亚组的患者可能同时具有BD和bvFTD的遗传易感性。
