Institute for Animal Production in the Tropics and Subtropics, University of Hohenheim, Stuttgart, Germany.
J Toxicol Environ Health B Crit Rev. 2010 Aug;13(6):476-507. doi: 10.1080/10937404.2010.499736.
Jatropha is a nonedible oil seed plant belonging to Euphorbiaceae family. Global awareness of sustainable and alternative energy resources has propelled research on Jatropha oil as a feedstock for biodiesel production. During the past two decades, several cultivation projects were undertaken to produce Jatropha oil. In future, the increased cultivation of toxic Jatropha plants and utilization of its agro-industrial by-products may raise the frequency of contact with humans, animals, and other organisms. An attempt was thus made to present known information on toxicity of Jatropha plants. The toxicity of Jatropha plant extracts from fruit, seed, oil, roots, latex, bark, and leaf to a number of species, from microorganisms to higher animals, is well established. Broadly, these extracts possess moluscicidal, piscicidal, insecticidal, rodenticidal, antimicrobial, and cytotoxic properties, and exert adverse effects on animals including rats, poultry, and ruminants. The toxicity attributed to these seeds due to their accidental consumption by children is also well documented. An attempt was also made to identify areas that need further study. The information provided in this review may aid in enhancing awareness in agroindustries involved in the cultivation, harvesting, and utilization of Jatropha plants and its products with respect to the potential toxicity of Jatropha, and consequently in application and enforcement of occupational safety measures. Data on the wide range of bioactivities of Jatropha and its products were collated and it is hoped will create new avenues for exploiting these chemicals by the phamaceutical industry to develop chemotherapeutic agents.
麻疯树是大戟科的一种不可食用的油料植物。人们对可持续和替代能源资源的全球意识推动了对麻疯树油作为生物柴油生产原料的研究。在过去的二十年中，开展了几个种植项目来生产麻疯树油。未来，随着有毒麻疯树植物的大量种植和其农业工业副产品的利用，人类、动物和其他生物与麻疯树接触的频率可能会增加。因此，试图介绍已知的麻疯树植物毒性信息。麻疯树植物果实、种子、油、根、乳胶、树皮和叶子提取物对许多物种的毒性，从微生物到高等动物，已经得到了充分证实。这些提取物具有杀软体动物、杀鱼类、杀虫、杀鼠、抗菌和细胞毒性等特性，并对包括大鼠、家禽和反刍动物在内的动物产生不良影响。由于儿童意外食用这些种子而导致的毒性也有充分的记录。还试图确定需要进一步研究的领域。本文综述提供的信息可能有助于增强从事麻疯树种植、收获和利用及其产品的农业产业的意识，了解麻疯树的潜在毒性，从而有助于实施和执行职业安全措施。收集了麻疯树及其产品广泛的生物活性数据，希望为制药业开发化疗药物提供新的途径，利用这些化学物质。
