用灭活疫苗保护雪貂免受猪源 2009 年 A（H1N1）流感病毒感染。
Protection of ferrets from infection by swine-origin 2009 A (H1N1) influenza virus by the inactivated vaccine.
机构信息
Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Yuseong-Gu, Daejeon, Korea.
出版信息
Viral Immunol. 2010 Aug;23(4):395-402. doi: 10.1089/vim.2010.0022.
Swine-origin pandemic 2009 A (H1N1) influenza viruses are still infecting humans, and humans are currently being vaccinated with the inactivated vaccine of 2009 A (H1N1) influenza virus. We wanted to determine the efficacy of 2009 A (H1N1) inactivated vaccine in ferrets. Ferrets immunized with one dose (7.5 microg) of 2009 A (H1N1) inactivated vaccine were not protected from infections of either pandemic H1N1 or seasonal H1N1 influenza viruses, while ferrets immunized with two doses of 2009 A (H1N1) inactivated vaccine were protected from infections of pandemic H1N1, but not seasonal H1N1 influenza viruses. IgG subtype of antibody was dominantly detected in tissues of immunized ferrets. Our study suggests that pandemic H1N1 vaccine may not elicit the antibody cross-reactive to the seasonal H1N1 influenza virus.
猪源大流行 2009 年 A（H1N1）流感病毒仍在感染人类，目前人类正在接种 2009 年 A（H1N1）流感病毒的灭活疫苗。我们想确定 2009 年 A（H1N1）流感灭活疫苗在雪貂中的效果。接受一剂（7.5 微克）2009 年 A（H1N1）流感灭活疫苗免疫的雪貂不能免受大流行 H1N1 或季节性 H1N1 流感病毒的感染，而接受两剂 2009 年 A（H1N1）流感灭活疫苗免疫的雪貂可免受大流行 H1N1 的感染，但不能免受季节性 H1N1 流感病毒的感染。在免疫雪貂的组织中检测到 IgG 亚型抗体占主导地位。我们的研究表明，大流行 H1N1 疫苗可能不会引起对季节性 H1N1 流感病毒的抗体交叉反应。
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