DeRossi Rafael, Bertoni Rodrigo A, Ruzzon Rafael Hs, Verde-Selva Alexandre B, Frazílio Fabrício O
Department of Veterinary Medicine-Surgery and Anesthesiology, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
Vet Anaesth Analg. 2010 Sep;37(5):451-9. doi: 10.1111/j.1467-2995.2010.00559.x.
To determine the analgesic and systemic effects of epidural administration of ketamine, lidocaine or a combination of ketamine/lidocaine in standing cattle.
Prospective, randomized, experimental trial.
Six healthy male cattle weighing between 335 and 373 kg.
The animals received 0.5 mg kg(-1) of ketamine (K), 0.2 mg kg(-1) of 2% lidocaine (L) or 0.25 mg kg(-1) ketamine plus 0.1 mg kg(-1) lidocaine (KL). All the drugs were injected into the dorsolumbar epidural space via a caudal approach through a non-styletted multiple-port catheter. Each animal received each treatment at random. Evaluations of analgesia, sedation, ataxia, heart rate, arterial pressure, respiratory rate, skin temperature and rectal temperature were obtained at 0 (basal), 5, 10, 15, 30, 45, 60, 75, 90 minutes after epidural injection, and then at 30-minute intervals until loss of analgesia occurred. Skin temperature was taken at these intervals up to 60 minutes. All the animals received a standard noxious stimulus; a 4-point scale was used to score the response. A second scale was used to score ataxia and a third for sedation.
The duration of analgesia in the upper and lower flanks in cattle was 140 +/- 15, 50 +/- 14 and 80 +/- 22 minutes (mean +/- SD) after dorsolumbar epidural KL, K or L, respectively. The cardiovascular changes were within acceptable limits in these clinically healthy cattle.
Dorsolumbar epidural administration of KL to cattle resulted in longer duration of analgesia of the upper and lower flanks in standing conscious cattle, than the administration of K or L alone.
Further research is necessary to determine whether this combination using this technique provides sufficient analgesia for flank surgery in standing cattle.
确定硬膜外注射氯胺酮、利多卡因或氯胺酮/利多卡因组合对站立牛的镇痛及全身影响。
前瞻性、随机、实验性试验。
6头健康雄性牛,体重335至373千克。
动物分别接受0.5毫克/千克的氯胺酮(K)、0.2毫克/千克的2%利多卡因(L)或0.25毫克/千克氯胺酮加0.1毫克/千克利多卡因(KL)。所有药物均通过无针芯多端口导管经尾侧途径注入背腰段硬膜外间隙。每头动物随机接受每种治疗。在硬膜外注射后0(基础)、5、10、15、30、45、60、75、90分钟进行镇痛、镇静、共济失调、心率、动脉压、呼吸频率、皮肤温度和直肠温度评估,然后每隔30分钟评估一次,直至镇痛效果消失。在这些时间间隔内测量皮肤温度,直至60分钟。所有动物均接受标准的有害刺激;使用4分制对反应进行评分。使用第二种评分制对共济失调进行评分,第三种评分制对镇静进行评分。
背腰段硬膜外注射KL、K或L后,牛上、下侧腹的镇痛持续时间分别为140±15、50±14和80±22分钟(平均值±标准差)。在这些临床健康的牛中,心血管变化在可接受范围内。
对牛进行背腰段硬膜外注射KL,与单独注射K或L相比,可使站立清醒牛的上、下侧腹镇痛持续时间更长。
有必要进一步研究这种技术使用这种组合是否能为站立牛的侧腹手术提供足够的镇痛效果。