肌动蛋白丝长度调节灵活交联肌动蛋白网络的弹性。
Actin filament length tunes elasticity of flexibly cross-linked actin networks.
机构信息
School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
出版信息
Biophys J. 2010 Aug 9;99(4):1091-100. doi: 10.1016/j.bpj.2010.06.025.
Abstract
Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers.
摘要
由顺应性蛋白细丝蛋白交联的细胞骨架生物聚合物肌动蛋白网络形成软凝胶，在切应力下会剧烈变硬。我们证明，与具有小而刚性交联的网络不同，这些网络的弹性强烈依赖于肌动蛋白聚合物的平均长度。这种行为与由多个柔性接头连接的刚性细丝模型一致。
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