根据青春期阶段，肥胖青少年的胰岛素样因子 3、抑制素 B 和瘦素浓度对睾丸功能的影响。
The effect of obesity on testicular function by insulin-like factor 3, inhibin B, and leptin concentrations in obese adolescents according to pubertal stages.
机构信息
Department of Clinical Biochemistry, Celal Bayar University, Faculty of Medicine, Manisa, Turkey.
出版信息
Clin Biochem. 2010 Oct;43(15):1236-40. doi: 10.1016/j.clinbiochem.2010.07.026. Epub 2010 Aug 14.
OBJECTIVES
The aim of the present study is to investigate the effect of obesity on testicular function by evaluating reproductive hormones, inhibinB, insulin-like 3(INSL3), and leptin, in obese and non-obese adolescents according to pubertal Tanner stages.
DESIGN AND METHODS
Eighty adolescent boys were grouped (n=20) as; Group1: obese-Tanner2, Group2: non-obese-Tanner2, Group3: obese-Tanner4, Group4: non-obese-Tanner4. Serum INSL3, luteinizing hormone, follicle-stimulating hormone, total testosterone, free testosterone, estradiol, sex hormone binding globulin, inhibin B and leptin levels were assessed in all groups.
RESULTS
INSL3 levels were significantly lower in obese adolescents compared to non-obese boys (p=0.003, Tanner2) and (p=0.031, Tanner4). There was a negative correlation between INSL3 and leptin (r=-0.468, p=0.001). The negative correlation between INSL3 and BMISDS indicates that pubertal obesity leads to Leydig cell impairment.
CONCLUSIONS
This study demonstrated for the first time in the literature that obesity effects testicular Leydig cell function starting from Tanner stage 2.
目的
本研究旨在通过评估肥胖和非肥胖青少年根据青春期 Tanner 分期的生殖激素、抑制素 B、胰岛素样 3（INSL3）和瘦素，来研究肥胖对睾丸功能的影响。
设计和方法
将 80 名青春期男孩分为 4 组（n=20）：组 1：肥胖-Tanner2，组 2：非肥胖-Tanner2，组 3：肥胖-Tanner4，组 4：非肥胖-Tanner4。评估所有组的 INSL3、促黄体生成素、卵泡刺激素、总睾酮、游离睾酮、雌二醇、性激素结合球蛋白、抑制素 B 和瘦素水平。
结果
与非肥胖男孩相比，肥胖青少年的 INSL3 水平显著降低（p=0.003，Tanner2 和 p=0.031，Tanner4）。INSL3 与瘦素之间存在负相关（r=-0.468，p=0.001）。INSL3 与 BMI SDS 的负相关表明青春期肥胖导致睾丸间质细胞损伤。
结论
本研究首次在文献中证明，肥胖从 Tanner 2 期开始影响睾丸间质细胞功能。
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