Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Diabetes Care. 2010 Nov;33(11):2462-4. doi: 10.2337/dc10-0595. Epub 2010 Aug 16.
To study the association of serum fetuin-A as a potential risk factor with abnormal albuminuria in Chinese individuals with normal glucose tolerance (NGT).
The cross-sectional analysis included 607 men and 1,042 women aged 40 or older with NGT.
Women with combined microalbuminuria and macroalbuminuria (n=68) had significantly higher serum fetuin-A concentrations than those with normal albumin excretion (n=974) (314.3 vs. 280.4 mg/l, P=0.007). Compared with the lowest quartile, the highest quartile of serum fetuin-A had 40% increased risk of abnormal albuminuria after the multiple adjustments in women (Pfor trend=0.02). However, the associations were not detected in men.
Higher serum fetuin-A was associated with abnormal albuminuria independent of BMI, waist circumference, homeostasis model assessment of insulin resistance, blood pressure, and other determinants of albuminuria in middle-aged and elderly Chinese women with NGT.
研究血清胎球蛋白 A 作为一个潜在的危险因素与中国糖耐量正常（NGT）人群白蛋白尿异常的关系。
横断面分析包括 607 名男性和 1042 名年龄在 40 岁及以上的 NGT 女性。
合并微量白蛋白尿和大量白蛋白尿的女性（n=68）的血清胎球蛋白 A 浓度明显高于正常白蛋白排泄的女性（n=974）（314.3 vs. 280.4 mg/L，P=0.007）。与最低四分位相比，女性血清胎球蛋白 A 的最高四分位数在多重调整后白蛋白尿异常的风险增加了 40%（Pfor 趋势=0.02）。然而，在男性中并未检测到这些关联。
在中年和老年中国 NGT 女性中，较高的血清胎球蛋白 A 与白蛋白尿异常相关，独立于 BMI、腰围、胰岛素抵抗评估的稳态模型、血压和白蛋白尿的其他决定因素。
