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Obtaining tomato plants transgenic for the preS2-S-HDEL gene, which synthesize the major hepatitis B surface antigen.

作者信息

Salyaev R K, Stolbikov A S, Rekoslavskaya N I, Shchelkunov S N, Pozdnyakov S G, Chepinoga A V, Hammond R V

机构信息

Siberian Institute of Plant Physiology and Biochemistry, Russian Academy of Sciences, Irkutsk, Russia.

出版信息

Dokl Biochem Biophys. 2010 Jul-Aug;433:187-90. doi: 10.1134/S1607672910040113. Epub 2010 Aug 17.

DOI:10.1134/S1607672910040113
PMID:20714853
Abstract
摘要

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本文引用的文献

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Expression of the human hepatitis B virus large surface antigen gene in transgenic tomato plants.人乙型肝炎病毒大表面抗原基因在转基因番茄植株中的表达。
Clin Vaccine Immunol. 2007 Apr;14(4):464-9. doi: 10.1128/CVI.00321-06. Epub 2007 Feb 21.
2
Oral immunogenicity of potato-derived HBsAg middle protein in BALB/c mice.马铃薯来源的乙肝表面抗原中间蛋白在BALB/c小鼠中的口服免疫原性。
Vaccine. 2007 Jan 5;25(3):577-84. doi: 10.1016/j.vaccine.2006.05.131. Epub 2006 Aug 10.
3
Immunogenicity in humans of an edible vaccine for hepatitis B.一种乙型肝炎可食用疫苗在人体中的免疫原性。
含乙肝病毒基因与该基因的重组真核表达质粒的构建与表达：其免疫调节作用的研究
Biomed Rep. 2013 Mar;1(2):251-256. doi: 10.3892/br.2012.47. Epub 2012 Dec 10.
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The twenty-year story of a plant-based vaccine against hepatitis B: stagnation or promising prospects?一种基于植物的乙肝疫苗的二十年历程：停滞不前还是前景光明？
Int J Mol Sci. 2013 Jan 21;14(1):1978-98. doi: 10.3390/ijms14011978.
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Plant expression, lyophilisation and storage of HBV medium and large surface antigens for a prototype oral vaccine formulation.用于原型口服疫苗制剂的 HBV 中、大表面抗原的植物表达、冷冻干燥和储存。
Plant Cell Rep. 2012 Mar;31(3):585-95. doi: 10.1007/s00299-011-1223-7. Epub 2012 Jan 14.
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3378-82. doi: 10.1073/pnas.0409899102. Epub 2005 Feb 22.
4
Fluorescent screening of transgenic Arabidopsis seeds without germination.未萌发的转基因拟南芥种子的荧光筛选
Plant Physiol. 2004 Jun;135(2):709-14. doi: 10.1104/pp.104.040709.
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Immunobiology of the Tomatine adjuvant.番茄碱佐剂的免疫生物学
Vaccine. 2004 Jun 23;22(19):2380-4. doi: 10.1016/j.vaccine.2004.03.022.
6
A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells.一种在植物细胞中表达的具有增强稳定性和免疫原性的植物信号肽-乙型肝炎表面抗原融合蛋白。
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2209-14. doi: 10.1073/pnas.0438037100. Epub 2003 Feb 24.
7
A plant-derived edible vaccine against hepatitis B virus.一种针对乙型肝炎病毒的植物源可食用疫苗。
FASEB J. 1999 Oct;13(13):1796-9. doi: 10.1096/fasebj.13.13.1796.
8
Novel hepatitis B vaccines.
Vaccine. 1998 Nov;16 Suppl:S65-8. doi: 10.1016/s0264-410x(98)00300-4.
9
The C-terminal HDEL sequence is sufficient for retention of secretory proteins in the endoplasmic reticulum (ER) but promotes vacuolar targeting of proteins that escape the ER.C 端的 HDEL 序列足以将分泌蛋白保留在内质网（ER）中，但会促进逃逸出内质网的蛋白质的液泡靶向运输。
Plant J. 1997 Feb;11(2):313-25. doi: 10.1046/j.1365-313x.1997.11020313.x.
10
The Arabidopsis endoplasmic reticulum retention receptor functions in yeast.拟南芥内质网滞留受体在酵母中发挥作用。
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