Géraud G, Viguie E, Arsenault A, Nutik S, Perey B, Dilenge D
Acta Radiol Suppl. 1976;347:87-98.
Sixty-four measurements of CBF were performed in 8 monkeys in supine and in sitting position under various conditions of ventilation. The position of the body does not normally influence the response of brain circulation to CO2. The response is not different from normal with high insufflation pressure in supine position and the capacities to autoregulation seem to be maintained. In vertical position however there are no longer any significant relations between CBF and PaCO2, and the loss of autoregulation seems to occur earlier and to be more marked. Correlation of these findings to neuroradiologic data indicates that the cerebral venous drainage through the meningospinal plexus is enhanced in vertical position and that during intrathoracic hyperpressure the cerebral venous blood is retained in the jugular vein and meningospinal plexus, thus decreasing the cerebral venous pressure increase and maintaining a perfusion of brain tissue compatible with the survival of the animal.
在8只猴子处于仰卧位和坐位的情况下，于不同通气条件下进行了64次脑血流量（CBF）测量。身体位置通常不会影响脑循环对二氧化碳的反应。在仰卧位时，高气腹压力下的反应与正常情况无异，并且似乎维持了自动调节能力。然而，在垂直位时，CBF与动脉血二氧化碳分压（PaCO2）之间不再存在任何显著关系，并且自动调节功能的丧失似乎更早发生且更为明显。这些发现与神经放射学数据的相关性表明，在垂直位时通过脑脊膜丛的脑静脉引流增强，并且在胸内高压期间，脑静脉血保留在颈静脉和脑脊膜丛中，从而减少了脑静脉压力的升高，并维持了与动物存活相适应的脑组织灌注。
