Department of Pharmaceutical Technology, University of Szeged, Szeged, Hungary.
Pharm Dev Technol. 2012 Jan-Feb;17(1):125-8. doi: 10.3109/10837450.2010.508076. Epub 2010 Aug 17.
The aim of this work was to investigate the skin penetration enhancer effect of a sucrose ester (SE) in an Ibuprofen (IBU) containing hydrogel and to examine its influence on the special lipid bilayer of the stratum corneum (SC). ATR-FTIR spectroscopic measurements were performed combined with tape stripping method on hairless mice in vivo. A SE containing gel was compared to another gel without SE. It was found that the preparations caused only minimal modifications in the lipid and the protein structure, promoting the skin hydration and therefore also the penetration of IBU. Although the degree of moisturization and penetration were more intense in the case of the SE containing gel treatment, it did not cause greater alterations in the SC structure than the gel without SE. It has been proven that SE acts as an effective and non-irritating hydration and penetration enhancer for IBU through skin.
本工作旨在研究蔗糖酯（SE）在含有布洛芬（IBU）的水凝胶中的皮肤渗透增强作用，并考察其对角质层（SC）特殊脂质双层的影响。采用ATR-FTIR 光谱测量法结合胶带剥离法对无毛小鼠进行了体内研究。将含有 SE 的凝胶与不含 SE 的凝胶进行了比较。结果发现，这些制剂仅对脂质和蛋白质结构产生最小的修饰，促进皮肤水合作用，从而也促进了 IBU 的渗透。尽管含有 SE 的凝胶处理在保湿和渗透程度上更为强烈，但它对 SC 结构的改变并不比不含 SE 的凝胶更大。已经证明 SE 通过皮肤对 IBU 起到有效且无刺激性的保湿和渗透增强作用。
