Department of Internal Medicine, Medical School, University of Ioannina, Greece.
Metab Syndr Relat Disord. 2010 Dec;8(6):523-9. doi: 10.1089/met.2010.0023. Epub 2010 Aug 17.
The aim of the study was to evaluate the relative importance of the determinants of the metabolic syndrome in a sample with metabolic syndrome from the Greek population.
A random sample of 824 male (56 ± 11 years) and 1,199 female (58 ± 10 years) subjects with metabolic syndrome [National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III)], but without diabetes mellitus or established cardiovascular disease, was selected from all over Greece. Principal components analysis (PCA) was applied to evaluate the interrelationships between the inherent characteristics of the metabolic syndrome.
Among the participants, 87.6% had elevated blood pressure levels, 79.9% had hypertriglyceridaemia, 62.6% had low high-density lipoprotein cholesterol (HDL-C) levels, 71.4% had impaired fasting glucose (FG), and 91.5% had abdominal obesity. The most common combination was elevated blood pressure levels, abdominal obesity, impaired fasting glucose (FG), and hypertriglyceridemia (14.2%). PCA revealed three main components that explained 68.4% of the total variation. The first one was heavily loaded by blood pressure (28.6% of the total variation explained), followed by a component characterized by lipid variables (21.7%) and a component characterized by FG and waist circumference measurements (18.1% explained variation).
The most dominant characteristic of metabolic syndrome participants from a Mediterranean country (Greece) was elevated blood pressure levels, which were present in all eight of the most common combinations of metabolic syndrome components, rendering the "hypertensive aspect" of metabolic syndrome the most common one. Because a significant proportion of hypertensive subjects with metabolic syndrome receive no treatment, or are poorly controlled, targeting blood pressure levels in the general population may assist in better preventing metabolic syndrome and its complications.
本研究旨在评估代谢综合征患者中决定因素的相对重要性，该患者样本来自希腊人群的代谢综合征。
从希腊各地随机选择了 824 名男性（56±11 岁）和 1199 名女性（58±10 岁）患有代谢综合征[美国国家胆固醇教育计划成人治疗专家组 III（NCEP ATP III）]但无糖尿病或已确诊心血管疾病的患者。采用主成分分析（PCA）评估代谢综合征固有特征之间的相互关系。
在参与者中，87.6%的人血压升高，79.9%的人甘油三酯升高，62.6%的人高密度脂蛋白胆固醇（HDL-C）水平降低，71.4%的人空腹血糖受损（FG），91.5%的人腹部肥胖。最常见的组合是血压升高、腹部肥胖、空腹血糖受损和甘油三酯升高（占 14.2%）。PCA 揭示了三个主要成分，它们解释了总变异的 68.4%。第一个主要成分主要与血压相关（占总变异的 28.6%），其次是一个以血脂变量为特征的成分（占 21.7%）和一个以 FG 和腰围测量为特征的成分（占 18.1%的变异得到解释）。
来自地中海国家（希腊）的代谢综合征患者的最主要特征是血压升高，这种情况存在于代谢综合征八个最常见的成分组合中，使得代谢综合征的“高血压方面”成为最常见的方面。由于相当一部分患有代谢综合征的高血压患者未接受治疗或治疗效果不佳，因此针对普通人群的血压水平可能有助于更好地预防代谢综合征及其并发症。
