Huo Da, Tao Lixin, Li Xia, Wang Wei, Wang Zhaoping, Chen Dongning, Zhu Huiping, Yang Xinghua, Luo Yanxia, Guo Xiuhua
School of Public Health, Capital Medical University, No, 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing 100069, China.
BMC Public Health. 2013 Oct 2;13:912. doi: 10.1186/1471-2458-13-912.
Raised blood pressure (BP) is associated with the incidence of metabolic syndrome (MetS). It is unknown if subjects with different BP levels may develop certain components of MetS over time. We investigated the incidence of MetS relative to different levels of BP over a 5-year period in a Chinese population in Tongren Hospital, Beijing.
During the period of 2006-2011, we recruited 2,781 participants with no MetS, or self-reported type 2 diabetes, dyslipidemia, hypertension, or cardiovascular disease at baseline. Association rule was used to identify the transitions of MetS components over time.
The incidence of MetS at follow-up was 9.74% for men and 3.21% for women in the group with optimal BP; 10.29% and 7.22%, respectively, in the group with normal BP; 10.49% and 10.84%, respectively, in the group with high-normal BP; and 14.48% and 23.21%, respectively in the group with high BP. The most common transition was from healthy to healthy in the groups with optimal or normal BP (17.9-49.3%), whereas in the high-normal BP group, 16.9-22.1% of subjects with raised BP returned to healthy status or stayed unchanged, while 13.8-21.4% of people with high BP tended to develop raised fasting glucose levels.
The incidence of MetS increased in parallel with the increase in BP. People with optimal and normal BP levels were less susceptible to developing MetS over time, whereas abnormal BP seemed to be a pre-existing phase of MetS. High-normal BP was a crucial status for MetS prevention.
血压升高与代谢综合征（MetS）的发病率相关。不同血压水平的个体是否会随着时间推移出现MetS的某些组分尚不清楚。我们在北京同仁医院的中国人群中调查了5年期间相对于不同血压水平的MetS发病率。
在2006年至2011年期间，我们招募了2781名基线时无MetS、或无自我报告的2型糖尿病、血脂异常、高血压或心血管疾病的参与者。采用关联规则来识别MetS组分随时间的转变。
随访时，最佳血压组男性的MetS发病率为9.74%，女性为3.21%；正常血压组分别为10.29%和7.22%；正常高值血压组分别为10.49%和10.84%；高血压组分别为14.48%和23.21%。最常见的转变是在最佳或正常血压组中从健康转变为健康（17.9 - 49.3%），而在正常高值血压组中，血压升高的受试者中有16.9 - 22.1%恢复到健康状态或保持不变，而高血压患者中有13.8 - 21.4%倾向于出现空腹血糖水平升高。
MetS的发病率随血压升高而平行增加。最佳和正常血压水平的个体随着时间推移患MetS的易感性较低，而异常血压似乎是MetS的一个前期阶段。正常高值血压是预防MetS的关键状态。
