血清中用于胃癌筛查的 DNA 甲基化生物标志物。
DNA methylation biomarkers in serum for gastric cancer screening.
机构信息
Department of Gastroenterology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200001, P.R. China.
出版信息
Mini Rev Med Chem. 2010 Oct;10(11):1034-8. doi: 10.2174/1389557511009011034.
Epigenetic alterations occur throughout the development and carcinogenesis of gastric cancer. Therefore, the detection of methylated DNA markers is predicted to be able to detect gastric cancer earlier, and improve the risk assessment, surveillance, relapse, and prognosis of patients with gastric cancer. Detection of free methylated DNA also represents a promising approach for developing serum-based detection methods for the non-invasive monitoring of gastric cancer progression.
表观遗传改变发生在胃癌的发生和发展过程中。因此，检测甲基化 DNA 标志物有望更早地检测到胃癌，并改善胃癌患者的风险评估、监测、复发和预后。游离甲基化 DNA 的检测也代表了开发基于血清的检测方法以非侵入性监测胃癌进展的一种很有前途的方法。
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