Zhang Yunzhu, Zhu Chunpeng, Lu Xinliang
Department of Gastroenterology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019 May 25;48(3):326-333. doi: 10.3785/j.issn.1008-9292.2019.06.14.
Early diagnosis is the key to improve the prognosis of gastric cancer. How to screen out high-risk subjects of gastric cancer in population is a hot spot. Serum-based early detection of gastric cancer is suitable for high-risk population screening, which is more convenient and safer. This article reviews the diagnostic value of serum biomarkers for gastric cancer, including serum DNA methylation, various RNAs, pepsinogen, gastrin, osteopontin, MG7-Ag and CA724. Until now, there is still lack of ideal biomarkers for gastric cancer, and searching for specific RNAs may be promising for early diagnosis and screening of gastric cancer.
早期诊断是改善胃癌预后的关键。如何在人群中筛查出胃癌高危人群是一个热点问题。基于血清的胃癌早期检测适用于高危人群筛查，更加便捷和安全。本文综述了血清生物标志物对胃癌的诊断价值，包括血清DNA甲基化、各种RNA、胃蛋白酶原、胃泌素、骨桥蛋白、MG7-Ag和CA724。到目前为止，仍然缺乏理想的胃癌生物标志物，寻找特异性RNA可能对胃癌的早期诊断和筛查具有前景。
