Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands.
Br J Dermatol. 2010 Nov;163(5):1099-101. doi: 10.1111/j.1365-2133.2010.09993.x.
Juvenile psoriasis is a chronic and incurable skin disease that affects approximately 0·7% of children.
To achieve more insight into the quality of life (QoL) in childhood psoriasis and to investigate whether disease severity scores correlate with QoL scores.
All consecutive patients with juvenile plaque psoriasis (≤ 18 years old) who visited our outpatient department were included. At baseline, the Children's Dermatology Life Quality Index (CDLQI) questionnaire was completed and disease severity was assessed by the Psoriasis Area and Severity Index (PASI) and the Physician Global Assessment (PGA).
Thirty-nine patients were included in the study. A median CDLQI of 6 [interquartile range (IQR) 5–9] was reported. Median PASI was 6·3 (IQR 3·3–8·2) and median PGA was 2 (IQR 1–3). The correlation coefficient between PASI and CDLQI was 0·47 (P = 0·003), whereas the correlation coefficient between PGA and CDLQI was 0·51 (P = 0·001).
The negative effect on QoL in juvenile psoriasis was confirmed in the largest cohort presented up to now. The correlation between disease severity scores and disease-related QoL in children with psoriasis is only moderate. Therefore, both clinical outcome parameters (PASI, PGA) and measures of QoL (CDLQI) should be included in adequate, patient-oriented clinical decision making.
青少年银屑病是一种慢性且无法治愈的皮肤病，约影响 0.7%的儿童。
深入了解儿童银屑病的生活质量（QoL），并探讨疾病严重程度评分是否与 QoL 评分相关。
纳入所有来我院门诊就诊的青少年斑块状银屑病（≤18 岁）患者。在基线时，完成儿童皮肤病生活质量指数（CDLQI）问卷，并通过银屑病面积和严重程度指数（PASI）和医生整体评估（PGA）评估疾病严重程度。
本研究共纳入 39 例患者。报告的 CDLQI 中位数为 6[四分位间距（IQR）5-9]。PASI 中位数为 6.3（IQR 3.3-8.2），PGA 中位数为 2（IQR 1-3）。PASI 与 CDLQI 之间的相关系数为 0.47（P=0.003），而 PGA 与 CDLQI 之间的相关系数为 0.51（P=0.001）。
在迄今为止呈现的最大队列中，确认了青少年银屑病对 QoL 的负面影响。银屑病儿童的疾病严重程度评分与疾病相关 QoL 之间的相关性仅为中度。因此，临床结局参数（PASI、PGA）和 QoL 措施（CDLQI）都应纳入适当的、以患者为导向的临床决策中。
