University of Medicine and Dentistry of New Jersey - School of Public Health and Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
Ann N Y Acad Sci. 2010 Aug;1203:160-7. doi: 10.1111/j.1749-6632.2010.05638.x.
Ambient air pollution has been linked to cardiovascular and respiratory morbidity and mortality in epidemiology studies. Frequently, oxidative and nitrosative stress are hypothesized to mediate these pollution effects, however precise mechanisms remain unclear. This paper describes the methodology for a major panel study to examine air pollution effects on these and other mechanistic pathways. The study took place during the drastic air pollution changes accompanying the 2008 Olympics in Beijing, China. After a general description of air pollution health effects, we provide a discussion of panel studies and describe the unique features of this study that make it likely to provide compelling results. This study should lead to a clearer and more precise definition of the role of oxidative and nitrosative stress, as well as other mechanisms, in determining acute morbidity and mortality from air pollution exposure.
大气污染与流行病学研究中的心血管和呼吸道发病率和死亡率有关。通常，氧化应激和硝化应激被认为是介导这些污染影响的机制，但确切的机制仍不清楚。本文介绍了一项大型面板研究的方法，以研究空气污染对这些和其他机制途径的影响。该研究在中国北京举办 2008 年奥运会期间空气污染急剧变化期间进行。在对空气污染对健康的影响进行了一般性描述之后，我们对面板研究进行了讨论，并描述了这项研究的独特特征，这些特征使该研究有可能提供有说服力的结果。这项研究有望更清晰、更精确地定义氧化应激和硝化应激以及其他机制在确定空气污染暴露引起的急性发病率和死亡率方面的作用。
