Clares B, Ruíz M A, Morales M E, Tamayo J A, Lara V Gallardo
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Granada, Granada, Spain.
J Cosmet Sci. 2010 Jul-Aug;61(4):269-78.
2-Dimethylaminoethanol (DMAE) (also known as deanol) has been used as an ingredient in skin care, and in cognitive function- and mood-enhancing products. It is marketed as a free base or salt, and in theory, the two forms should be equally effective and able to substitute for each other in pharmaceutical formulations. Detecting possible alterations in the active principle is a basic part of preformulation studies. Accordingly, this study compared DMAE and DMAE bitartrate to identify potential alterations or differences between the free base and the salt that might compromise the long-term stability of cosmetic preparations at different temperatures, and also compared the behavior of the base substance and derivative alone and in solution. Samples were analyzed with different physicochemical methods such as differential scanning calorimetry, ultraviolet and infrared spectroscopy, and nuclear magnetic resonance spectroscopy.
2-二甲基氨基乙醇（DMAE）（也称为地阿诺）已被用作护肤品以及增强认知功能和改善情绪产品中的一种成分。它以游离碱或盐的形式销售，理论上，这两种形式在药物制剂中应具有同等效力且能够相互替代。检测活性成分可能发生的变化是制剂前研究的一个基本部分。因此，本研究比较了DMAE和酒石酸氢DMAE，以确定游离碱和盐之间可能影响不同温度下化妆品制剂长期稳定性的潜在变化或差异，还比较了基础物质及其衍生物单独存在时以及在溶液中的行为。使用差示扫描量热法、紫外和红外光谱法以及核磁共振光谱法等不同的物理化学方法对样品进行了分析。
