Department of Paediatrics, University of British Columbia and BC Children's Hospital, Vancouver, BC, Canada.
J Rheumatol. 2010 Nov;37(11):2415-21. doi: 10.3899/jrheum.100083. Epub 2010 Aug 17.
The Research on Arthritis in Canadian Children Emphasizing Outcomes (ReACCh Out) cohort is a prospective inception cohort of patients with newly diagnosed juvenile idiopathic arthritis (JIA) seen in 16 Canadian pediatric rheumatology (PR) centers. We used data from this cohort to explore factors associated with longer time from symptom onset to the first visit to (PR), and with longer time from first visit to a diagnosis of JIA.
We included children enrolled in ReACCh Out within 6 months of JIA diagnosis, for whom the dates of symptom onset and first PR visit were recorded. We used Cox proportional hazard modeling to investigate the effects of history, physical examination, and laboratory evaluation on the interval from JIA symptom onset to first PR assessment.
In total, 319 children from the cohort were included. Having a fever (hazard ratio 1.80, 95% CI 1.10, 2.93), any part South Asian ethnicity (HR 1.75, 95% CI 1.04, 2.95), highly educated parents (HR 1.69, 95% CI 1.18, 2.44), and limp (HR 1.55, 95% 1.16, 2.06) were significantly associated with shorter time from symptom onset to first PR assessment, while a history of heel pain or enthesitis (HR 0.61, 95% 0.38, 0.97) was significantly associated with a longer time to first PR visit.
Children with a history of a fever, limp, any part South Asian ethnicity, or highly educated parents were more likely to see PR sooner than patients without these features, while children with a history of enthesitis received PR care later than those without enthesitis.
加拿大儿童关节炎研究(ReACCh Out)队列是一个新诊断的幼年特发性关节炎(JIA)患者的前瞻性发病队列,在加拿大 16 个儿科风湿病学(PR)中心就诊。我们使用该队列的数据来探讨与从症状出现到首次就诊(PR)时间较长以及从首次就诊到 JIA 诊断时间较长相关的因素。
我们纳入了在 JIA 诊断后 6 个月内入组 ReACCh Out 的患儿,记录了症状出现和首次 PR 就诊的日期。我们使用 Cox 比例风险模型来研究病史、体格检查和实验室评估对 JIA 症状出现到首次 PR 评估的间隔时间的影响。
队列中共有 319 名患儿被纳入研究。发热(危险比 1.80,95%置信区间 1.10,2.93)、任何南亚裔族群(HR 1.75,95%置信区间 1.04,2.95)、父母受教育程度较高(HR 1.69,95%置信区间 1.18,2.44)和跛行(HR 1.55,95%置信区间 1.16,2.06)与从症状出现到首次 PR 评估的时间较短显著相关,而足跟痛或附着点炎的病史(HR 0.61,95%置信区间 0.38,0.97)与首次 PR 就诊时间较长显著相关。
有发热、跛行、任何南亚裔族群或父母受教育程度较高病史的患儿比没有这些特征的患儿更有可能更早地看 PR,而有附着点炎病史的患儿比没有附着点炎的患儿接受 PR 治疗的时间更晚。